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Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats.

Author: GabaglioMarina, ManentiCristina, ParolaroDaniela, RubinoTiziana, ZamberlettiErica

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the long-term effects of chronic administration of a THC/CBD combination in female rats. The study found that a 3:1 ratio of THC:CBD mitigated some of the long-term behavioral alterations induced by adolescent THC exposure. However, a 33:1 ratio of CBD:THC had long-term adverse effects on cognition and led to anhedonia.
Paper Details　
Original Abstract of the Article :
Cannabis is the most-used recreational drug worldwide, with a high prevalence of use among adolescents. In animal models, long-term adverse effects were reported following chronic adolescent exposure to the main psychotomimetic component of the plant, delta-9-tetrahydrocannabinol (THC). However, the...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396365/

データ提供：米国国立医学図書館（NLM）

THC and CBD: Exploring the Complexities of Cannabis Use in Adolescence

Cannabis use, particularly among adolescents, is a complex issue with long-term consequences. This study, published in the journal Neuropharmacology, investigated the effects of chronic adolescent exposure to different combinations of THC and CBD, the primary psychoactive compounds in cannabis.

The researchers used female rats as a model system, exposing them to different combinations of THC and CBD during adolescence. They found that chronic exposure to a THC-rich/CBD-poor combination had long-term adverse effects on cognitive function and behavior. On the other hand, CBD-rich/THC-poor combinations mitigated some of the adverse effects of THC. This is like navigating a desert with different levels of shade – too much direct sun exposure can be harmful, but a balance of sun and shade can lead to a more comfortable journey.

The Impact of Cannabis on the Brain: A Complex and Evolving Landscape

The study highlights the complexity of cannabis use, particularly during adolescence. It emphasizes the importance of understanding the interplay between different cannabinoids and the potential risks associated with THC-rich cannabis products. This is like exploring a vast and ever-changing desert, where careful navigation is essential to avoid potential dangers.

Navigating the Journey: A Call for Responsible Cannabis Use

The findings of this study underscore the need for responsible cannabis use, especially among adolescents. It highlights the importance of carefully considering the potential risks and benefits of different cannabis products. Just as a desert traveler chooses a safe and sustainable route, individuals should make informed decisions about cannabis use to protect their health and well-being.

Dr. Camel's Conclusion

This study delves into the complex effects of chronic cannabis use, particularly during adolescence. It highlights the importance of understanding the unique characteristics of different cannabis products and the potential risks associated with THC-rich combinations. Like a wise camel traveler navigating a complex desert environment, individuals should make informed decisions about cannabis use to ensure a safe and healthy journey.

Date :
  1. Date Completed 2021-09-20
  2. Date Revised 2021-09-20
Further Info :

Pubmed ID

34445602

DOI: Digital Object Identifier

PMC8396365

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Languages

English

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