Side Effects of dronabinol: A Synthesis of Findings from 23 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of dronabinol: A Synthesis of Findings from 23 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Dronabinol can cause side effects such as loss of appetite, nausea, and vomiting. 5 23 9 7 13

Dronabinol may increase heart rate or cause arrhythmias. 10 17

Dronabinol can be addictive. 16 12

Dronabinol can interact with other medications. 20 3

CBD is generally well tolerated, but some studies indicate the possibility of adverse effects with chronic high-dose CBD use. 11

In animal models, CBD has been shown to mitigate some of the adverse effects of THC. 22

Low doses of CBD (< 7.5mg/day) can reduce opioid use in patients with chronic pain. 19

Reasons for Side Effects

The side effects of dronabinol are thought to be caused by its effects on cannabinoid receptors (CB1 receptor and CB2 receptor) in the body. CB1 receptors are abundant in the brain, digestive system, heart, liver, etc. and affect appetite, mood, memory, motor function, pain, and immune responses. CB2 receptors are mainly present in immune cells and are involved in inflammatory and immune responses. 11

Common Side Effects

Appetite Changes

Dronabinol can increase appetite. This effect is due to its action on CB1 receptors. This side effect can be beneficial for patients with conditions such as anorexia nervosa, but it is important to consider the potential for weight gain. 5

Nausea and Vomiting

Dronabinol can cause nausea and vomiting. This is due to its action on CB1 receptors. If you experience nausea or vomiting, consult your doctor. 5

Fatigue

Dronabinol can cause fatigue. This effect is due to its action on CB1 receptors. If you feel tired, avoid dangerous activities such as lifting heavy objects or driving, and consult your doctor. 5

Dizziness

Dronabinol can cause dizziness. This is due to its action on CB1 receptors. If you feel dizzy, be careful when getting up and avoid falling. 5

Anxiety

Dronabinol can cause anxiety. This is due to its action on CB1 receptors. If you experience anxiety, consult your doctor. 5

Hallucinations and Auditory Hallucinations

Dronabinol can cause hallucinations and auditory hallucinations. This effect is due to its action on CB1 receptors. If you experience hallucinations or auditory hallucinations, consult your doctor. 5

Effects on the Heart

Dronabinol can affect the heart and cause increased heart rate and arrhythmias. 10 17

Addiction

Dronabinol can be addictive. Follow your doctor's instructions and do not stop taking it or increase the dose without consulting your doctor. 16 12

Side Effect Management

Appetite Changes

If you are concerned about changes in your appetite, talk to your doctor. They may advise you on diet and exercise. 5

Nausea and Vomiting

If you are concerned about nausea or vomiting, talk to your doctor. They may prescribe anti-nausea or anti-vomiting medications. 5

Fatigue

If you are concerned about fatigue, talk to your doctor. Make sure you get enough rest. 5

Dizziness

If you are concerned about dizziness, be careful when getting up and avoid falling. Talk to your doctor and get prescribed medication if necessary. 5

Anxiety

If you are concerned about anxiety, talk to your doctor. They may prescribe medication to help reduce your anxiety. 5

Hallucinations and Auditory Hallucinations

If you are concerned about hallucinations or auditory hallucinations, talk to your doctor. It is important to get the right treatment. 5

Effects on the Heart

If you have any concerns about your heart, talk to your doctor before taking dronabinol. 10 17

Addiction

Dronabinol can be addictive. Follow your doctor's instructions and do not stop taking it or increase the dose without consulting your doctor. 16 12

Comparison Between Studies

Commonalities

These studies suggest that dronabinol may be an effective treatment for a variety of conditions. 5 23 9 7 13

Differences

These studies differ in terms of the conditions studied, the research methods used, and the results obtained. 5 23 9 7 13 10 17 16 12 20 3

Points to Note Regarding Real-World Application

Dronabinol may be an effective treatment for a variety of conditions. However, the risk of side effects must also be considered. When using dronabinol, it is important to talk to your doctor and follow their instructions. 5 23 9 7 13

Limitations of Current Research

There is still not enough research on the safety and efficacy of dronabinol. 5 23 9 7 13

Future Research Directions

More research is needed on the safety and efficacy of dronabinol. 5 23 9 7 13

Conclusion

Dronabinol may be an effective treatment for a variety of conditions, but the risk of side effects must also be considered. When using dronabinol, it is important to talk to your doctor and follow their instructions. 5 23 9 7 13

Literature analysis of 23 papers
Positive Content
17
Neutral Content
2
Negative Content
4
Article Type
2
0
0
6
23
1.

A double-blind randomised controlled trial of paracetamol, diclofenac or the combination for pain relief after caesarean section.

Author: MunishankarB, FettesP, MooreC, McLeodG A

Pain relief

A combination of diclofenac and paracetamol was found to be more effective in reducing morphine use after elective caesarean section than paracetamol alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of Pipemidic Acid, Phenazopyridine HCL and Sodium Diclofenac on Pain Perception Following Endoscopic Urological Surgery: Double-blinded Randomized-Controlled Trial.

Author: YuriPrahara, AliZulfikar, RasyidNur, BirowoPonco

Pain relief
Endoscopic urological surgery

Oral analgesics, including pipemidic acid, phenazopyridine, and sodium diclofenac, were effective in reducing pain after endoscopic urological surgery in 80 patients. Pipemidic acid demonstrated a superior analgesic effect compared to the other two drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Effects of concomitant use of THC and irinotecan on tumour growth and biochemical markers in a syngeneic mouse model of colon cancer.

Author: ŽunecSuzana, KaračonjiIrena Brčić, ČatalinacMartin, JuričAndreja, KatićAnja, KozinaGoran, MicekVedran, NeubergMarijana, VrdoljakAna Lucić

Reduced toxicity
Diminished efficacy

This study investigated the effects of combining irinotecan, a chemotherapy drug, with THC, the active ingredient in cannabis, on a mouse model of colorectal cancer. The combination was found to reduce the effectiveness of irinotecan in inhibiting tumor growth.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Can we predict the treatment doses of THC and CBD and does it matter?

Author: HalamishNitzan, SchleiderLihi Bar-Lev, McGuireSydney, NovackVictor

This study aimed to develop a model for predicting stable THC and CBD dosages in patients using medical cannabis after six months of treatment. The model utilizes baseline patient characteristics to personalize cannabis treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

[Cannabidiol (CBD): Analytical and toxicological aspects].

Author: AlvarezJean-Claude, PelissierAnne-Laure, MuraPatrick, GoulléJean-Pierre

CBD toxicity
THC positive tests

Cannabidiol (CBD), a non-psychoactive compound found in cannabis, is increasingly used for various purposes. This study examined the analytical methods for quantifying CBD and its metabolites in biological samples, particularly saliva and blood. It also discussed the potential for CBD to be transformed into THC, the psychoactive component of cannabis, and the toxicity associated with CBD.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

11.

THC and CBD: Similarities and differences between siblings.

Author: StellaNephi

CBD therapeutic properties
THC therapeutic properties
CBD side effects
THC impairments
THC mental health issues

This review examines the distinct mechanisms of action and biological activities of THC and CBD, focusing on their effects on human behavior and diseases. While both compounds show therapeutic potential, chronic THC use is associated with mental health problems, and high-dose CBD can have significant side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

14.

The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence.

Author: ArnoldJonathon C, McCartneyDanielle, SuraevAnastasia, McGregorIain S

Anti-addiction effects
Reduced anxiety

Oral CBD doses of 300-400 mg per day showed evidence of reducing anxiety and having anti-addiction effects. Lower doses (less than 300 mg) may have some benefits, but more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Current Cannabidiol Safety: A Review.

Author: SinghChander, RaoKomal, YadavNikita, VashistYogesh, ChughPalak, BansalNidhi, MinochaNeha

Anti-inflammatory
Psychoactive effects

This review discusses cannabidiol (CBD), a non-psychoactive isomer of tetrahydrocannabinol (THC), and some of its associated patents.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research.

Author: GalajEwa, HempelBriana, MooreAllamar, KleinBenjamin, BiGuo-Hua, GardnerEliot L, SeltzmanHerbert H, XiZheng-Xiong

Cocaine use disorder treatment

PIMSR, a neutral CB1R antagonist, has shown promise as a pharmacotherapeutic for cocaine use disorder, demonstrating dose-dependent inhibition of cocaine self-administration and cue-induced reinstatement of cocaine seeking, without adverse effects, and warrants further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Language : English

17.

Marijuana and endothelial dysfunction: new mechanism and therapy.

Author: FengXiaojun, XuSuowen, WengJianping

Cannabis side effect treatment

This study found that soy isoflavone genistein can attenuate Δ9-tetrahydrocannabinol (Δ9-THC)-induced endothelial dysfunction and atherosclerosis by directly antagonizing peripheral cannabinoid receptor 1. These findings suggest a potential therapeutic approach for ameliorating the cardiovascular side effects of cannabis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

18.

Guideline No. 425a: Cannabis Use Throughout Women's Lifespans - Part 1: Fertility, Contraception, Menopause, and Pelvic Pain.

Author: RobertMagali, GravesLisa E, AllenVictoria M, DamaSumeet, GabrysRobert L, TanguayRobert L, TurnerSuzanne D, GreenCourtney R, CookJocelynn L

None reported
Cannabis use safety

Cannabis use in women is becoming more common, but there are still gaps in knowledge about its impact on women's health. This review summarizes evidence on cannabis use, safety, and care for women who use cannabis.

Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?

Author: LordSarah, HardyJanet, GoodPhillip

cancer symptom relief
drug interactions

Cannabidiol (CBD) is being investigated as a potential treatment for symptoms in patients with advanced cancer. While CBD is generally well tolerated, there are concerns regarding drug interactions and lack of research on its role in specific symptoms. Further research is needed to understand its efficacy and optimal dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats.

Author: GabaglioMarina, ZamberlettiErica, ManentiCristina, ParolaroDaniela, RubinoTiziana

Mitigated THC side effects
Anhedonia
Cognitive impairment

This study investigated the long-term effects of chronic administration of a THC/CBD combination in female rats. The study found that a 3:1 ratio of THC:CBD mitigated some of the long-term behavioral alterations induced by adolescent THC exposure. However, a 33:1 ratio of CBD:THC had long-term adverse effects on cognition and led to anhedonia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

A Phase-2 Pilot Study of a Therapeutic Combination of &#916;<sup>9</sup>-Tetrahydracannabinol and Palmitoylethanolamide for Adults With Tourette's Syndrome.

Author: BlochMichael H, Landeros-WeisenbergerAngeli, JohnsonJessica A, LeckmanJames F

Tourette's treatment

This study investigated the safety, tolerability, and dosing of THX-110, a combination of Δ9-tetrahydrocannabinol (Δ9-THC) and palmitoylethanolamide (PEA), in Tourette's syndrome.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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