Antitumor effects of the multi-target tyrosine kinase inhibitor cabozantinib: a comprehensive review of the preclinical evidence.

Author: ColonnaValentina, IacovelliRoberto, KlinzStephan, MauriGiorgio, NutiMarianna, SantoniMatteo

Paper Details 
Original Abstract of the Article :
Altered receptor tyrosine kinase (RTK) signaling contributes to tumorigenesis and suppression of immune-mediated destruction of cancer cells. Cabozantinib is an oral tyrosine kinase inhibitor that inhibits several RTKs involved in tumorigenesis, and is approved for the treatment of patients with pro...See full text at original site
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引用元:
https://doi.org/10.1080/14737140.2021.1919090

データ提供:米国国立医学図書館(NLM)

Cabozantinib: A Multi-Target Tyrosine Kinase Inhibitor for Cancer Treatment

The fight against cancer is a complex and multifaceted battle, with researchers constantly seeking new and effective therapies. This review article delves into the preclinical evidence for cabozantinib, a multi-target tyrosine kinase inhibitor, as a potential treatment for various types of cancer. The researchers examine how cabozantinib works, targeting multiple receptor tyrosine kinases (RTKs) that are involved in tumorigenesis, the process by which normal cells transform into cancerous cells. The review highlights the evidence supporting cabozantinib's potential as a treatment for advanced cancers, including medullary thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma.

A New Weapon in the Arsenal Against Cancer

Cabozantinib's multi-target approach could offer a significant advantage in treating cancer. By targeting multiple pathways involved in tumor growth and spread, cabozantinib could potentially be more effective than single-target drugs.

Understanding Cancer Treatment

Cancer treatment is a complex and personalized journey, with various treatment options available. This review emphasizes the importance of ongoing research in developing new and effective therapies for cancer, offering hope for those battling this devastating disease.

Dr. Camel's Conclusion

Just as a camel adapts to the harsh desert environment by developing unique survival strategies, researchers are continuously searching for innovative approaches to combat cancer. This review explores the potential of cabozantinib as a promising new treatment, highlighting the importance of targeting multiple pathways involved in cancer growth. It underscores the ongoing fight against cancer and the relentless pursuit of better treatment options for patients.

Date :
  1. Date Completed 2022-03-03
  2. Date Revised 2022-03-03
Further Info :

Pubmed ID

34445927

DOI: Digital Object Identifier

10.1080/14737140.2021.1919090

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SNS
PICO Info
in preparation
Languages

English

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