Severe Epistaxis Secondary to Dabrafenib and Trametinib Toxicity in Non-small Cell Lung Carcinoma With Small Bowel Metastasis.

Author: GullapalliKeerthi, HrinczenkoBorys, MosalemOsama, VargheseMerryl T, WatatKevin

Paper Details 
Original Abstract of the Article :
BRAF mutations are estimated to be present in 2-4% of non-small cell lung carcinoma (NSCLC) cases. BRAF inhibitor (dabrafenib) and MEK inhibitor (trametinib) are currently approved to treat NSCLC harboring the BRAF V600E mutation. However, the use of this new combined targeted therapy can be associa...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396418/

データ提供:米国国立医学図書館(NLM)

Severe Epistaxis Secondary to Dabrafenib and Trametinib Toxicity

The field of oncology is constantly evolving, striving to find treatments that are as effective as a camel's endurance in traversing a vast desert. This case report describes a patient with non-small cell lung carcinoma who experienced severe epistaxis, a serious nosebleed, as a side effect of a combined targeted therapy with dabrafenib and trametinib. The authors emphasize the importance of recognizing and managing potential side effects associated with these new targeted therapies.

Unmasking the Potential Side Effects of Targeted Therapies

This case report serves as a reminder that even with the development of highly targeted therapies, unexpected side effects can still occur. It highlights the importance of carefully monitoring patients receiving these therapies and being prepared to manage potential complications. Imagine a desert expedition encountering unexpected storms, necessitating a change in plans. Just like a seasoned explorer, medical professionals must be adaptable and prepared for unexpected challenges.

Navigating the Landscape of Cancer Treatment

This case report underscores the importance of ongoing research and vigilance in managing the side effects of new cancer treatments. It provides valuable insights for physicians and patients alike, emphasizing the need for open communication and a collaborative approach to care. Just as a caravan navigates the desert together, a strong doctor-patient relationship is crucial for navigating the challenging journey of cancer treatment.

Dr.Camel's Conclusion

This case report highlights the potential for severe side effects associated with the combined targeted therapy of dabrafenib and trametinib. It serves as a cautionary tale, emphasizing the importance of meticulous patient monitoring and the need for ongoing research to optimize the safety and efficacy of these therapies. As we continue to explore new frontiers in cancer treatment, it's important to proceed with both optimism and caution, like a wise camel traversing the ever-changing desert landscape.
Date :
  1. Date Completed n.d.
  2. Date Revised 2021-09-03
Further Info :

Pubmed ID

34466299

DOI: Digital Object Identifier

PMC8396418

SNS
PICO Info
in preparation
Languages

English

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