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Severe Epistaxis Secondary to Dabrafenib and Trametinib Toxicity in Non-small Cell Lung Carcinoma With Small Bowel Metastasis.
Author: GullapalliKeerthi, HrinczenkoBorys, MosalemOsama, VargheseMerryl T, WatatKevin
Original Abstract of the Article :
BRAF mutations are estimated to be present in 2-4% of non-small cell lung carcinoma (NSCLC) cases. BRAF inhibitor (dabrafenib) and MEK inhibitor (trametinib) are currently approved to treat NSCLC harboring the BRAF V600E mutation. However, the use of this new combined targeted therapy can be associa...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396418/
データ提供:米国国立医学図書館(NLM)
Severe Epistaxis Secondary to Dabrafenib and Trametinib Toxicity
The field of oncology is constantly evolving, striving to find treatments that are as effective as a camel's endurance in traversing a vast desert. This case report describes a patient with non-small cell lung carcinoma who experienced severe epistaxis, a serious nosebleed, as a side effect of a combined targeted therapy with dabrafenib and trametinib. The authors emphasize the importance of recognizing and managing potential side effects associated with these new targeted therapies.Unmasking the Potential Side Effects of Targeted Therapies
This case report serves as a reminder that even with the development of highly targeted therapies, unexpected side effects can still occur. It highlights the importance of carefully monitoring patients receiving these therapies and being prepared to manage potential complications. Imagine a desert expedition encountering unexpected storms, necessitating a change in plans. Just like a seasoned explorer, medical professionals must be adaptable and prepared for unexpected challenges.Navigating the Landscape of Cancer Treatment
This case report underscores the importance of ongoing research and vigilance in managing the side effects of new cancer treatments. It provides valuable insights for physicians and patients alike, emphasizing the need for open communication and a collaborative approach to care. Just as a caravan navigates the desert together, a strong doctor-patient relationship is crucial for navigating the challenging journey of cancer treatment.Dr.Camel's Conclusion
This case report highlights the potential for severe side effects associated with the combined targeted therapy of dabrafenib and trametinib. It serves as a cautionary tale, emphasizing the importance of meticulous patient monitoring and the need for ongoing research to optimize the safety and efficacy of these therapies. As we continue to explore new frontiers in cancer treatment, it's important to proceed with both optimism and caution, like a wise camel traversing the ever-changing desert landscape.Date :
- Date Completed n.d.
- Date Revised 2021-09-03
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