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Gut microbiota mediated the therapeutic efficacies and the side effects of prednisone in the treatment of MRL/lpr mice.

Author: BaoJie, HeZhixing, LiHaichang, LinXiaoying, WangMingzhu, WenChengping, ZhuZhengyang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the role of gut microbiota in mediating the effects of glucocorticoids (GCs) in treating systemic lupus erythematosus (SLE). The study found that prednisone had a dose-dependent effect on gut microbiota. Fecal microbiota transplantation (FMT) of prednisone-regulated gut microbiota alleviated lupus in MRL/lpr mice, suggesting that gut microbiota may be a therapeutic target for SLE.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence to prove whether gut microbiota directly mediates the effects of GCs. METHODS...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439074/

データ提供：米国国立医学図書館（NLM）

Prednisone and Gut Microbiota in Lupus: A Desert of Interconnectedness

This research explores the complex interplay between prednisone, a common treatment for systemic lupus erythematosus (SLE), and the gut microbiota, like an archaeologist uncovering the hidden connections between ancient civilizations. The authors, like skilled desert detectives, investigate the impact of [treatment] on the gut microbiota and its implications for SLE treatment. Their research offers valuable insights into the interconnectedness of the gut microbiome and immune system, providing a new perspective on the effectiveness and side effects of prednisone in SLE management.

A Shifting Landscape of Gut Microbiota

The study found [key findings]. This research offers a glimpse into the intricate relationship between prednisone, gut microbiota, and SLE, suggesting that manipulating the gut microbiome may be a promising approach for improving treatment outcomes and reducing side effects.

A Desert Oasis of Gut Health

This research underscores the importance of [recommendations for action] to optimize the effectiveness of prednisone therapy and to minimize potential side effects. It's like finding a hidden oasis in the vast and often challenging desert of SLE treatment, offering a pathway towards a better understanding of the gut microbiome and its role in immune health.

Dr.Camel's Conclusion

Systemic lupus erythematosus (SLE) is a complex and challenging autoimmune disease, and the search for effective treatments continues. This research offers a new perspective on the role of gut microbiota in SLE management, suggesting that targeting the gut microbiome may be a promising approach for enhancing treatment outcomes and reducing side effects. It's like discovering a hidden oasis in the vast and often challenging desert of SLE treatment, offering a pathway towards a brighter future for those living with this debilitating condition.

Date :
  1. Date Completed 2021-10-28
  2. Date Revised 2021-10-28
Further Info :

Pubmed ID

34521450

DOI: Digital Object Identifier

PMC8439074

Related Literature

Article Analysis
・Side Effects of prednisone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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