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Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase.

Author: AzimiFateme, HassanzadehFarshid, HassanzadehMotahareh, Homayouni MoghadamFarshad, KhodarahmiGhadam Ali, NadriHamid, RostamiMahbobe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Alzheimer's disease is a leading cause of elderly death worldwide. Acetylcholinesterase (AChE) inhibitors like donepezil and rivastigmine are commonly used to treat Alzheimer's disease, but their therapeutic effects are limited, and they can cause significant side effects.
Paper Details　
Original Abstract of the Article :
Alzheimer's disease is considered one of the lead causes of elderly death around the world. A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer's disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely u...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407153/

データ提供：米国国立医学図書館（NLM）

Isoindoline-1,3-dione Derivatives: A Potential Solution for Alzheimer's Disease

This study delved into the synthesis and bioevaluation of new isoindoline-1,3-dione derivatives as potential inhibitors of acetylcholinesterase (AChE). AChE inhibitors are currently used to treat Alzheimer's disease, a devastating neurodegenerative disorder, but they often have limited therapeutic effects and significant side effects. This research seeks to develop new and potentially more effective inhibitors for the treatment of Alzheimer's disease.

New Hope for Alzheimer's Disease Treatment

The findings suggest that these new isoindoline-1,3-dione derivatives may offer a promising avenue for treating Alzheimer's disease. It's like finding a hidden oasis in the vast desert of Alzheimer's research, offering a potential solution for this debilitating condition.

Combating Alzheimer's Disease: A Collaborative Effort

This research underscores the importance of collaboration and innovation in addressing complex neurological diseases. It's like a caravan crossing the desert, each member contributing their expertise to reach a common goal. By working together, we can continue to advance our understanding and treatment options for Alzheimer's disease.

Dr.Camel's Conclusion

This research reminds me of the ongoing journey to find a cure for Alzheimer's disease. It's like a camel traversing the vast and challenging desert, seeking out new and effective treatments for this devastating condition. The search continues, but with every new discovery, we move closer to a brighter future for those affected by Alzheimer's disease.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-26
Further Info :

Pubmed ID

34522196

DOI: Digital Object Identifier

PMC8407153

Related Literature

Article Analysis
・Side Effects of rivastigmine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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