Side Effects of rivastigmine: A Synthesis of Findings from 27 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of rivastigmine: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Rivastigmine is a medication used to treat Alzheimer's disease. 26 states that it enhances cholinergic neurotransmission in the brain by delaying the breakdown of acetylcholine, a neurotransmitter involved in various bodily functions. 1 found that rivastigmine patches are equally effective as capsules in improving daily living activities in Alzheimer's patients but with a lower incidence of gastrointestinal side effects. However, the risk of overdose exists with the patch formulation, potentially leading to fatal outcomes if multiple patches are applied simultaneously. 10 . Research suggests that transdermal rivastigmine offers a better tolerability profile compared to the oral form and other cholinesterase inhibitors. 10

Reasons for Side Effects

Side effects of rivastigmine are likely due to its mechanism of action, which is inhibition of acetylcholinesterase. This leads to an increase in acetylcholine levels, which can cause various side effects. .

Common Side Effects

Nausea and Vomiting

Nausea and vomiting are among the most common side effects of rivastigmine. 1 found that rivastigmine patches have a lower incidence of gastrointestinal side effects compared to the oral form, but these side effects can still occur. 11 states that transdermal rivastigmine causes fewer gastrointestinal side effects than the oral formulation.

Constipation

Rivastigmine can cause constipation. 12 states that rivastigmine is one of many drugs that can cause constipation.

Weight Loss

Rivastigmine can cause weight loss. 12 states that rivastigmine is one of many drugs that can cause weight loss.

Indigestion

Rivastigmine can cause indigestion. 12 states that rivastigmine is one of many drugs that can cause indigestion.

Rash

Rivastigmine can cause a rash. 24 states that rivastigmine is one of the drugs that can cause a rash.

Loss of Consciousness

Rivastigmine can cause loss of consciousness. 9 states that rivastigmine is one of the drugs that can cause loss of consciousness.

Changes in Heart Rate

Rivastigmine can cause changes in heart rate. 5 states that rivastigmine is one of the drugs that can cause changes in heart rate.

Changes in Blood Pressure

Rivastigmine can cause changes in blood pressure. 5 states that rivastigmine is one of the drugs that can cause changes in blood pressure.

Liver Dysfunction

Rivastigmine can cause liver dysfunction. states that rivastigmine is one of the drugs that can cause liver dysfunction.

Hypertrichosis

Rivastigmine can cause hypertrichosis, which is excessive hair growth in any area of the skin surface. 24

Measures to Counteract Side Effects

Nausea and Vomiting

It is recommended to take rivastigmine with food to reduce nausea and vomiting. 12 .

Constipation

It is recommended to drink plenty of fluids to reduce constipation. 12 .

Weight Loss

It is recommended to eat a high-calorie diet to reduce weight loss. 12 .

Indigestion

It is recommended to eat small, frequent meals to reduce indigestion. 12 .

Rash

Consult your doctor if you develop a rash. 24 .

Loss of Consciousness

Consult your doctor immediately if you experience loss of consciousness. 9 .

Changes in Heart Rate

Consult your doctor if you experience changes in heart rate. 5 .

Changes in Blood Pressure

Consult your doctor if you experience changes in blood pressure. 5 .

Liver Dysfunction

If liver dysfunction occurs, you should stop taking rivastigmine. .

Comparison between Studies

Commonalities among Studies

Multiple studies have demonstrated rivastigmine's effectiveness in improving Alzheimer's disease symptoms. However, they also highlight the potential for side effects such as nausea, vomiting, constipation, and weight loss. , 12 , 1 , 11 .

Differences between Studies

The incidence and severity of rivastigmine side effects vary across studies. 11 notes that transdermal rivastigmine causes fewer gastrointestinal side effects than the oral formulation. 10 suggests that the transdermal rivastigmine patch has a better tolerability profile compared to both the oral form and other cholinesterase inhibitors.

Points to Note Regarding Application in Real Life

While rivastigmine holds promise for improving Alzheimer's symptoms, it's essential to consider the potential for side effects. Always follow your doctor's instructions carefully when taking rivastigmine and consult them immediately if you experience any adverse reactions. It is also crucial to inform your doctor about any other medications you are taking, as rivastigmine can interact with other drugs. .

Limitations of Current Research

Research on rivastigmine remains limited. Further studies are needed to thoroughly investigate the long-term safety and efficacy of rivastigmine. Additionally, more research is required to understand the mechanisms behind rivastigmine's side effects and to develop methods for mitigating them. , 10 .

Future Research Directions

Future research should focus on further investigating the long-term safety and efficacy of rivastigmine. It is also imperative to conduct more research on the mechanisms behind rivastigmine's side effects and to explore methods for mitigating them. , 10 .

Conclusion

Rivastigmine offers potential benefits for improving Alzheimer's symptoms, but its potential for side effects should not be disregarded. Always adhere to your doctor's instructions when taking rivastigmine and report any side effects promptly. , 12 , 1 , 11 .

Literature analysis of 27 papers
Positive Content
25
Neutral Content
2
Negative Content
0
Article Type
1
0
1
12
26
1.

Impact of rivastigmine patch and capsules on activities of daily living in Alzheimer's disease.

Author: GrossbergGeorge, MengXiangyi, OlinJason T

Improved ADLs

Rivastigmine patches and capsules demonstrated significant improvement in activities of daily living (ADLs) in patients with probable Alzheimer's disease (AD) compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Which rivastigmine formula is better for heart in elderly patients with Alzheimer's disease: oral or patch?

Author: IsikAhmet Turan, SoysalPinar, YayAdnan

There were no significant changes in any of the ECG parameters in all of the patients (P > .05) except heart rate (P = .035). Rivastigmine formulations were not associated with increased arrhythmogenic or hypotensive effects in elderly patients with AD and was not superior to each other.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Cardiovascular effects of drugs used to treat Alzheimer's disease.

Author: HowesLaurence Guy

Alzheimer's treatment
Bradycardia
QT prolongation
Syncope
Torsades de pointes

Drugs for Alzheimer's disease, such as acetylcholinesterase inhibitors (ACHIs) and memantine, are generally safe but may have rare cardiovascular side effects. Further research is needed to investigate the potential benefits of ACHIs for cardiovascular health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells.

Author: LiuEtta Y L, MakShinghung, KongXiangpeng, XiaYingjie, KwanKenneth K L, XuMiranda L, TsimKarl W K

Treats Alzheimer's disease
Apoptosis
ER stress

This study reports that tacrine and other acetylcholinesterase inhibitors (AChEIs) disrupt the proper trafficking of acetylcholinesterase in the endoplasmic reticulum, leading to apoptosis of neurons and other cells. This finding provides guidance for the design and discovery of AChEIs for Alzheimer's disease treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

A Novel Formulation: Donepezil Patch.

Author: AdelmanMegan, LouisLora

Donepezil patch efficacy
Improved dysphagia management
Reduced side effect burden

This analysis reviews the efficacy, safety, tolerability, and clinical considerations related to a novel patch formulation of donepezil, a drug used to treat dementia. The patch formulation may be beneficial for patients with dysphagia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia.

Author: SzetoJennifer Y Y, LewisSimon J G

Side effects of pharmacological treatments

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders. This review discusses pharmacological and non-pharmacological treatments for cognitive impairment in AD and PD patients, as well as treatment options for other neuropsychiatric and behavioral symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Alzheimer's disease treatment: The share of herbal medicines.

Author: SoheiliMasoud, KarimianMohammad, HamidiGholamali, SalamiMahmoud

Prevention of disease progression
Relief of symptoms

This review explores the therapeutic potential of phytomedicines for treating Alzheimer's disease (AD). Several herbal remedies, including *Lavandula angustifolia*, *Ginkgo biloba*, *Melissa officinalis*, *Crocus sativus*, *Ginseng*, *Salvia miltiorrhiza*, and *Magnolia officinalis*, have shown promising effects in addressing various factors associated with AD development and progression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase.

Author: HassanzadehMotahareh, HassanzadehFarshid, KhodarahmiGhadam Ali, RostamiMahbobe, AzimiFateme, NadriHamid, Homayouni MoghadamFarshad

Treats Alzheimer's disease
Side effects

Alzheimer's disease is a leading cause of elderly death worldwide. Acetylcholinesterase (AChE) inhibitors like donepezil and rivastigmine are commonly used to treat Alzheimer's disease, but their therapeutic effects are limited, and they can cause significant side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Tacrine and its derivatives in the therapy of Alzheimers disease].

Author: KorábečnýJan, SpilovskáKatarína, BenekOndřej, MusílekKamil, SoukupOndřej, KučaKamil

Behavioral improvement
Cognitive improvement
Functional improvement
Gastrointestinal discomfort
Hepatotoxicity

Cholinesterase inhibitors are the main drugs used to treat Alzheimer's disease. Tacrine, the first cholinesterase inhibitor approved for treatment, had significant side effects. This review summarizes research on newer tacrine analogues, which aim to provide similar benefits with fewer side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Czech

18.

[Support for the medication monitoring of patients with alzheimer's dementia by the interactive care system using IT].

Author: SakataYoshifumi, KubotaMasakazu, UemuraKengo, KiharaTakeshi, KimuraToru, InoTadashi, TsujiTeruyuki, HayashiMichiyuki, KinoshitaAyae

Care burden reduction
Medication compliance improvement
QOL improvement

This study investigates the potential of using video phone to improve medication compliance in patients with dementia who are using a rivastigmine patch for Alzheimer's disease.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

19.

Rivastigmine for vascular cognitive impairment.

Author: BirksJacqueline, McGuinnessBernadette, CraigDavid

Improved cognitive function

Vascular dementia is the second most common type of dementia after Alzheimer's disease. The review suggests that cholinesterase inhibitors, which are effective in treating Alzheimer's disease, may also be beneficial for vascular dementia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

The use of medications approved for Alzheimer's disease in autism spectrum disorder: a systematic review.

Author: RossignolDaniel A, FryeRichard E

ASD symptom improvement
Side effects

This review examines studies on the use of Alzheimer's disease medications for autism spectrum disorder (ASD). While there is evidence suggesting potential benefits for some medications, further research is needed to determine their efficacy and safety in treating ASD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Approach to Cognitive Impairment in Parkinson's Disease.

Author: ZhangQiang, AldridgeGeorgina M, NarayananNandakumar S, AndersonSteven W, UcErgun Y

Improved quality of life
Cognitive side effects

Cognitive problems are common in Parkinson's disease and can worsen over time. This study discusses the causes of these problems and possible treatment options, including medications, exercise, and cognitive training.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

France Will No More Reimburse Available Symptomatic Drugs Against Alzheimer's Disease.

Author: Krolak-SalmonPierre, DuboisBruno, SellalFrançois, Delabrousse-MayouxJean-Philippe, VandelPierre, AmievaHélène, JeandelClaude, AndrieuSandrine, Perret-LiaudetArmand

Alzheimer's disease treatment
Significant side effects

This study argues against the French Ministry of Health's decision to remove drugs used to treat Alzheimer's disease from the list of available reimbursed drugs. The authors contend that the evidence-based medicine related to these drugs reaches a high level in the literature and the ratio of benefits/risks favors these drugs.

EditorialAn article in which the editor or publisher expresses their opinion or perspective on a particular topic or issue. Its purpose is to convey a specific message or idea to the reader.

Language : English

24.

Acquired Localized Hypertrichosis Induced by Rivastigmine.

Author: Imbernón-MoyaAdrian, PodlipnikSebastian, BurgosFernando, Vargas-LagunaElena, Aguilar-MartínezAntonio, Fernández-CogolludoEva, Gallego-ValdesMiguel Angel

Alzheimer's disease treatment
Hypertrichosis

Rivastigmine, an acetylcholinesterase inhibitor used for Alzheimer's disease, caused localized hypertrichosis in a patient. This case highlights the rare potential for this side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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