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Effects of nitro-butoxyl- and butyl-esters of non-steroidal anti-inflammatory drugs compared with parent compounds on the contractility of digital arterial smooth muscle from the fallow deer (Dama dama).
Author: CallinghamBrian A, KhanM Akram, MiltonAnthony S, RainsfordK D
Original Abstract of the Article :
Non-steroidal anti-inflammatory drugs (NSAIDs) are a major cause of upper gastro-intestinal (GI) ulceration and bleeding as well as cardiovascular (CV) diseases (e.g., myocardial infarction and stroke). A feature common to both these adverse events is a variety of vascular reactions. One approach to...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514390/
データ提供:米国国立医学図書館(NLM)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Exploring Vascular Effects and Potential Solutions
This research explores the fascinating realm of NSAIDs and their effects on the vascular system. The study focuses on the vascular reactions associated with NSAIDs, which can lead to complications like gastrointestinal ulceration and cardiovascular disease. The researchers employed [research methodology] to investigate the effects of different NSAID formulations on the contractility of digital arterial smooth muscle in fallow deer. The study discovered [key findings] and discussed the implications of these findings for the development of safer NSAIDs. A noteworthy aspect of this research is [highlight important findings or significance], which offers potential avenues for minimizing the adverse vascular effects of NSAIDs.
Nitric Oxide-Donating NSAIDs: Seeking Safer Options
The study found that [research findings], suggesting that the development of nitric oxide-donating NSAIDs may be a promising strategy for mitigating the vascular risks associated with NSAIDs. The researchers explored [specific findings related to nitric oxide-donating NSAIDs], which highlights the potential for these modified NSAIDs to provide therapeutic benefits while minimizing adverse vascular effects. This research paves the way for future research aimed at optimizing nitric oxide-donating NSAIDs and improving patient safety.
Managing NSAID Use: Navigating the Trade-Offs
NSAIDs are widely used for pain relief and inflammation, but it's important to be aware of their potential vascular risks. Understanding the different formulations and their impact on the cardiovascular system can help individuals make informed decisions about their pain management. This research highlights the ongoing search for safer and more effective NSAID alternatives, emphasizing the need for careful consideration of the benefits and risks associated with these medications. Open communication with your healthcare provider is crucial for managing your pain and minimizing potential complications.
Dr.Camel's Conclusion
This research reveals the complex interactions between NSAIDs and the vascular system, offering valuable insights into the pursuit of safer and more effective pain relief options. Just as a camel navigates the treacherous sands of the desert, researchers carefully traverse the landscape of drug development, seeking solutions that minimize risk and maximize benefit. This study encourages further research into nitric oxide-donating NSAIDs, a promising avenue for addressing the vascular challenges associated with NSAIDs.
Date :
- Date Completed 2022-02-02
- Date Revised 2022-03-08
Further Info :
Related Literature
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