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Molecular surveillance for polymorphisms associated with artemisinin-based combination therapy resistance in Plasmodium falciparum isolates collected in Mozambique, 2018.
Author: AídePedro, BassatQuique, CandrinhoBaltazar, ChidimatembueArlindo, De CarvalhoEva, EnosseSónia, GoldmanIra, HalseyEric S, LucchiNaomi W, MaceteEusébio, MayorAlfredo, NhacoloArsénio, NhamaAbel, NhamussuaLídia, SaifodineAbuchahama, SalvadorCrizólgo, SvigelSamaly S, UdhayakumarVenkatachalam, ZulligerRose
Original Abstract of the Article :
Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaquine (A...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507114/
データ提供：米国国立医学図書館（NLM）
Plasmodium falciparum: Tracking the Shifting Sands of Malaria Resistance
Malaria is a deadly parasitic disease that continues to pose a significant threat to global health. This study focuses on the emergence of drug resistance in _Plasmodium falciparum_, the most dangerous species of malaria parasite. The researchers investigated the prevalence of genetic polymorphisms associated with artemisinin-based combination therapy (ACT) resistance in _P. falciparum_ isolates collected in Mozambique. This study uses a molecular surveillance approach, a crucial tool for tracking the evolution of drug resistance in parasites.
The Shifting Sands of Drug Resistance
The study found that the prevalence of genetic polymorphisms associated with ACT resistance was relatively low in the _P. falciparum_ isolates collected in Mozambique. This is a positive finding, suggesting that ACT remains an effective treatment option in this region. It's like finding a clear path through the desert of malaria resistance. However, the study emphasizes the importance of ongoing surveillance to track the emergence and spread of drug resistance. It is crucial to stay vigilant and adapt our treatment strategies to keep pace with the evolving landscape of drug resistance.
Staying One Step Ahead in the Fight Against Malaria
This study highlights the critical role of molecular surveillance in combating malaria. It's like a group of explorers navigating a desert, constantly scanning the horizon for signs of danger. By carefully tracking the emergence and spread of drug resistance, we can develop effective treatment strategies and prevent the spread of resistant parasites. This research underscores the importance of ongoing surveillance and collaborative efforts to combat this deadly disease.
Dr.Camel's Conclusion
This study provides valuable insights into the current status of ACT resistance in _Plasmodium falciparum_, highlighting the importance of ongoing surveillance and collaborative efforts to prevent the spread of drug resistance and ensure effective malaria control.
Date :
- Date Completed 2022-01-12
- Date Revised 2022-01-12
Further Info :
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