Paper Details

  1. Home
  2. Paper Details

Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates <i>In Vitro</i> and in a Mouse Model of Pulmonary Infection.

Author: ChitraSurya, EichelmanBenjamin, KeepersTiffany R, LamichhaneGyanu, MaggioncaldaEmily C, NicklasDanielle A, SerioAlisa W, Story-RollerElizabeth, TaborChavis

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the activity of omadacycline, a new tetracycline derivative, against Mycobacteroides abscessus, a difficult-to-treat nontuberculous mycobacterium. Omadacycline demonstrated potent in vitro activity against a panel of M. abscessus isolates, including those resistant to commonly used antibiotics. In a mouse model of lung infection, omadacycline showed promising efficacy, reducing bacterial load and exhibiting bactericidal activity.
Paper Details　
Original Abstract of the Article :
The incidence of nontuberculous mycobacterial diseases in the United States is rising and has surpassed that of tuberculosis. Most notable among the nontuberculous mycobacteria is Mycobacteroides abscessus, an emerging environmental opportunistic pathogen capable of causing chronic infections. M. ab...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765394/

データ提供：米国国立医学図書館（NLM）

Omadacycline: A Promising New Weapon Against Mycobacteroides abscessus

Nontuberculous mycobacteria (NTM) are an increasingly common challenge in the fight against infectious diseases, posing a significant threat to human health. This study focuses on Mycobacteroides abscessus, a particularly troublesome NTM, and investigates the efficacy of omadacycline, a new tetracycline derivative, in treating M. abscessus infections.

The authors demonstrate that omadacycline exhibits potent activity against M. abscessus both in vitro and in vivo. The drug showed promising results, particularly against strains resistant to traditional antibiotics. Furthermore, omadacycline displayed synergistic effects when combined with other antimicrobials, offering a potential advantage in treating multidrug-resistant infections. This study provides strong evidence for the potential of omadacycline as a new treatment option for M. abscessus infections.

New Horizons in Antibiotic Therapy

This research highlights the importance of developing novel antibiotics to combat the growing threat of antibiotic resistance. The results suggest that omadacycline could offer a valuable addition to the arsenal of antimicrobials used to treat NTM infections.

A New Path to Combating Resistance

The emergence of multidrug-resistant bacteria poses a significant challenge to public health. This study provides a glimmer of hope in the ongoing battle against resistance, demonstrating the effectiveness of omadacycline against a particularly troublesome NTM. By exploring and developing novel antibiotics, we can better protect ourselves from the threat of infectious diseases.

Dr.Camel's Conclusion

Like a resilient desert plant thriving in harsh conditions, omadacycline shows promise in the fight against antibiotic resistance. This study demonstrates its effectiveness against M. abscessus, a formidable foe in the world of infectious diseases. With continued research and development, we can hope to overcome the challenges posed by antibiotic resistance and ensure the availability of effective treatments for future generations.

Date :
  1. Date Completed 2022-03-22
  2. Date Revised 2022-03-22
Further Info :

Pubmed ID

34662184

DOI: Digital Object Identifier

PMC8765394

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.