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Effects of estradiol on fat in men undergoing androgen deprivation therapy: a randomized trial.
Author: CheungAda S, GrossmannMathis, HandelsmanDavid J, HoermannRudolf, RussellNicholas, ZajacJeffrey D
Original Abstract of the Article :
OBJECTIVE: Indirect evidence suggests that the effects of testosterone on fat mass in men are dependent on aromatization to estradiol (E2). However, no controlled study has assessed the effects of E2 in the absence of testosterone. DESIGN: Six-month randomized, placebo-controlled trial with the hyp...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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引用元:
https://pubmed.ncbi.nlm.nih.gov/34678758
データ提供:米国国立医学図書館(NLM)
Estradiol and Fat Mass in Men Undergoing Androgen Deprivation Therapy
This research dives deep into the fascinating world of hormones and their influence on fat distribution. It's like trying to unravel a mystery in the vast desert of our bodies, where each hormone plays a crucial role. This study specifically focuses on the impact of estradiol (E2), a type of estrogen, on fat mass in men receiving androgen deprivation therapy, a treatment often used for prostate cancer.
The researchers used a clever approach, a randomized controlled trial, to compare the effects of E2 gel with a placebo over a period of six months. They discovered a curious finding: E2 may actually increase total and regional fat mass in men, even in the absence of testosterone. While this result isn't statistically significant yet, it's definitely something to ponder upon, like a mirage in the desert that requires further investigation.
The Significance of This Finding
These findings could have important implications for the management of prostate cancer, particularly when considering the role of hormone therapy. It's like finding a hidden oasis in the desert of medical knowledge, where we need to tread carefully to fully understand the potential consequences. Further research is needed to confirm or refute this observation, so we can determine if E2 is truly a friend or foe when it comes to fat regulation in men.
Implications for Health and Lifestyle
This study is a reminder that the interplay of hormones is complex and multifaceted, just like the intricate network of dunes in a desert. It highlights the need for careful consideration of hormone therapies and their potential effects on overall health, especially in the context of conditions like prostate cancer. More research is needed to decipher this complex interplay and develop personalized approaches to manage hormone-related health concerns.
Dr.Camel's Conclusion
This study is a reminder that even in the vast and seemingly well-mapped desert of medical knowledge, there are still many hidden oases waiting to be discovered. We must continue to explore these mysteries with patience and an open mind, for each new finding can illuminate a path towards better health and well-being.
Date :
- Date Completed 2021-12-14
- Date Revised 2022-04-28
Further Info :
Related Literature
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