Effects of estradiol on fat in men undergoing androgen deprivation therapy: a randomized trial.

Author: CheungAda S, GrossmannMathis, HandelsmanDavid J, HoermannRudolf, RussellNicholas, ZajacJeffrey D

Paper Details 
Original Abstract of the Article :
OBJECTIVE: Indirect evidence suggests that the effects of testosterone on fat mass in men are dependent on aromatization to estradiol (E2). However, no controlled study has assessed the effects of E2 in the absence of testosterone. DESIGN: Six-month randomized, placebo-controlled trial with the hyp...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/34678758

データ提供:米国国立医学図書館(NLM)

Estradiol and Fat Mass in Men Undergoing Androgen Deprivation Therapy

This research dives deep into the fascinating world of hormones and their influence on fat distribution. It's like trying to unravel a mystery in the vast desert of our bodies, where each hormone plays a crucial role. This study specifically focuses on the impact of estradiol (E2), a type of estrogen, on fat mass in men receiving androgen deprivation therapy, a treatment often used for prostate cancer.

The researchers used a clever approach, a randomized controlled trial, to compare the effects of E2 gel with a placebo over a period of six months. They discovered a curious finding: E2 may actually increase total and regional fat mass in men, even in the absence of testosterone. While this result isn't statistically significant yet, it's definitely something to ponder upon, like a mirage in the desert that requires further investigation.

The Significance of This Finding

These findings could have important implications for the management of prostate cancer, particularly when considering the role of hormone therapy. It's like finding a hidden oasis in the desert of medical knowledge, where we need to tread carefully to fully understand the potential consequences. Further research is needed to confirm or refute this observation, so we can determine if E2 is truly a friend or foe when it comes to fat regulation in men.

Implications for Health and Lifestyle

This study is a reminder that the interplay of hormones is complex and multifaceted, just like the intricate network of dunes in a desert. It highlights the need for careful consideration of hormone therapies and their potential effects on overall health, especially in the context of conditions like prostate cancer. More research is needed to decipher this complex interplay and develop personalized approaches to manage hormone-related health concerns.

Dr.Camel's Conclusion

This study is a reminder that even in the vast and seemingly well-mapped desert of medical knowledge, there are still many hidden oases waiting to be discovered. We must continue to explore these mysteries with patience and an open mind, for each new finding can illuminate a path towards better health and well-being.

Date :
  1. Date Completed 2021-12-14
  2. Date Revised 2022-04-28
Further Info :

Pubmed ID

34678758

DOI: Digital Object Identifier

EJE-21-0663

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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