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Full Opioid Agonists and Tramadol: Pharmacological and Clinical Considerations.

Author: CauseyChristopher D, CornettElyse M, EdinoffAmber N, ImaniFarnad, KaplanLeah A, KayeAdam M, KayeAlan D, KhanSami, Moradi MoghadamOmid, PetersenMurray, SauceEmily

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Opioids are mu receptor agonists and have been used for pain management for centuries. Understanding opioid pharmacology is crucial for their safe and effective use in treating pain, opiate-induced side effects, and withdrawal syndromes. Commonly used full agonist opioids include heroin, morphine, codeine, oxycodone, meperidine, and fentanyl. Methadone, a diphenylheptane, is a long-acting synthetic opioid with high oral efficacy. Fentanyl is a potent phenylpiperdine derivative, 50-100 times more potent than morphine. Meperidine is another phenylpiperdine. Tramadol is a mixed-mechanism opioid that binds mu receptors and blocks monoamine reuptake. Common adverse effects of opioids include nausea, vomiting, pruritus, addiction, respiratory depression, constipation, and miosis. Chronic use is linked to opioid-induced hypogonadism and adrenal suppression. Physicians must carefully consider the risks and benefits before prescribing opioids.
Paper Details　
Original Abstract of the Article :
Opioids are mu receptor agonists and have been an important part of pain treatment for thousands of years. In order to use these drugs appropriately and successfully in patients, whether to control pain, to treat opiate-induced side effects, or opiate withdrawal syndromes, a solid understanding of t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520671/

データ提供：米国国立医学図書館（NLM）

Opioid Agonists and Tramadol: A Journey Through the Desert of Pain Management

This study takes us on a journey through the vast and complex desert of opioid analgesia, exploring the pharmacological properties and clinical considerations of various opioid medications used to manage pain. The authors delve into the nuances of different opioid agonists, including their mechanisms of action, therapeutic effects, and potential side effects. The study emphasizes the importance of careful opioid prescribing practices, considering the potential for addiction, respiratory depression, and other adverse events. This research provides a valuable guide for healthcare professionals navigating the intricate landscape of opioid use in pain management.

Navigating the Desert of Opioid Prescribing

The research highlights the importance of careful opioid prescribing practices, considering the potential for addiction and other adverse events. Like a desert traveler carefully navigating a treacherous landscape, clinicians must weigh the benefits of pain relief against the risks associated with opioid use. The study emphasizes the need for individualized treatment plans, considering factors such as patient history, risk factors, and potential alternatives to opioids. This research provides valuable insights into the complex landscape of opioid prescribing, empowering clinicians to make informed decisions and ensure the safest possible outcomes for their patients.

A Desert of Considerations for Pain Management

This research underscores the importance of a thoughtful and balanced approach to opioid prescribing in pain management. By carefully considering the risks and benefits, utilizing appropriate safeguards, and exploring alternative pain management strategies, clinicians can navigate the complex desert of opioid use, ensuring the best possible outcomes for their patients.

Dr. Camel's Conclusion

Navigating the desert of pain management requires a careful balance between providing relief and minimizing risks. This research helps us understand the nuances of opioid use, reminding us to approach this powerful class of medications with caution, individualized care, and a commitment to patient safety.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-07
Further Info :

Pubmed ID

34692448

DOI: Digital Object Identifier

PMC8520671

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Languages

English

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