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Associations between cognition and subsequent mood episodes in patients with bipolar disorder and their unaffected relatives: A systematic review.

Author: JahnFrida Simon, KjærstadHanne Lie, MariegaardJohanna, MiskowiakKamilla Woznica

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Cognitive impairment, poorer verbal memory and executive function, and positive bias were associated with subsequent (hypo)manic relapse in patients with bipolar disorder. Impairments in attention, verbal memory and executive functions, and positive bias were associated with subsequent illness onset in first-degree relatives.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Bipolar disorder (BD) is highly recurrent and prevention of relapse and illness onset is an urgent treatment priority. This systematic review examined whether cognitive assessments can aid prediction of recurrence in patients with BD and/or illness onset in individuals at familial risk. ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2021.10.044

データ提供：米国国立医学図書館（NLM）

Cognitive Clues in the Bipolar Desert: Predicting Mood Episodes

This systematic review explores the complex relationship between cognition and mood episodes in patients with bipolar disorder (BD) and their unaffected relatives. The review examined a total of 19 longitudinal studies investigating the association between cognitive function and subsequent relapse or illness onset. The review revealed that cognitive impairments, particularly in verbal memory and executive functions, along with positive bias, were associated with subsequent (hypo)manic relapses in patients with BD. In first-degree relatives, impairments in attention, verbal memory, executive functions, and positive bias were linked to subsequent illness onset.

Navigating the Bipolar Landscape: Cognitive Markers as Predictors of Mood Episodes

This review highlights the potential for cognitive assessments to aid in predicting mood episodes in patients with BD and their relatives. The study suggests that individuals with specific cognitive impairments may be at increased risk of experiencing mood episodes. While further research is needed to confirm these findings, the study provides valuable insights into the complex interplay between cognition and mood in BD.

Understanding the Mind in the Bipolar Desert: Implications for Treatment and Prevention

The findings of this review have significant implications for the treatment and prevention of mood episodes in BD. They suggest that personalized treatment approaches, tailored to individual cognitive profiles, could potentially improve outcomes. Early identification and interventions targeting cognitive impairments may also play a crucial role in preventing the onset of mood episodes in individuals at risk.

Dr.Camel's Conclusion

Think of the mind as a vast and ever-shifting desert landscape. For individuals with BD, this landscape can be particularly volatile, with periods of intense sandstorms (manic episodes) alternating with periods of calm (remission). This review suggests that certain cognitive features, like lost oases of memory and executive function, might serve as warning signs of impending sandstorms. Understanding these cognitive clues can help us navigate the bipolar landscape, potentially leading to more effective therapies and preventive strategies for those who brave this challenging terrain.
Date :
  1. Date Completed 2022-01-25
  2. Date Revised 2022-01-25
Further Info :

Pubmed ID

34699850

DOI: Digital Object Identifier

10.1016/j.jad.2021.10.044

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・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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