Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.

Author: DaveSandeep, GinsburgGeoffrey S, MyersRachel A, OrtelThomas L, VooraDeepak, WaldropAlexander

Paper Details 
Original Abstract of the Article :
Aspirin has known effects beyond inhibiting platelet cyclooxygenase-1 (COX-1) that have been incompletely characterized. Transcriptomics can comprehensively characterize the on- and off-target effects of medications. We used a systems pharmacogenomics approach of aspirin exposure in volunteers coupl...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/34705291

データ提供:米国国立医学図書館(NLM)

Aspirin: A Complex Medication with Unforeseen Effects

Aspirin, a familiar remedy, is often used to prevent cardiovascular disease. However, its effects go beyond inhibiting platelet COX-1, impacting the platelet transcriptome in a complex manner. This research explores the dose-independent effects of aspirin on platelet gene expression and its paradoxical association with increased platelet function. It's like discovering a hidden oasis in the desert that appears to have both refreshing and disorienting effects.

Aspirin's Impact on Platelet Gene Expression: A Paradoxical Effect

The study reveals that aspirin alters the platelet transcriptome, leading to an unexpected increase in platelet function despite its known antiplatelet effects. This suggests that aspirin's actions are more complex than previously understood. It's like finding a mirage that seems to refresh you but also leaves you feeling slightly off balance.

Aspirin and Platelet Function

Understanding aspirin's complex effects on platelet gene expression is crucial for optimizing its use in cardiovascular disease prevention and treatment. It's important to carefully consider the potential benefits and risks, as aspirin's actions might not always be straightforward. It's like navigating a desert oasis that appears to have both benefits and drawbacks, requiring careful assessment before venturing in.

Dr.Camel's Conclusion

This research reveals a dose-independent effect of aspirin on platelet gene expression, leading to a paradoxical increase in platelet function. This discovery highlights the complexity of aspirin's actions and underscores the importance of understanding its multifaceted effects.

Date :
  1. Date Completed 2022-04-12
  2. Date Revised 2023-05-02
Further Info :

Pubmed ID

34705291

DOI: Digital Object Identifier

NIHMS1751843

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English

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