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Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids.

Author: EstesMary K, FujiiYoshiki, HayashiTsuyoshi, HiranoJunki, MurakamiKosuke, MuramatsuMasamichi, OhashiHirofumi, WatashiKoichi, YamaokaYoko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Human noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups. This study screened an antiviral compound library using a human intestinal enteroid (HIE) culture system to identify compounds with anti-HuNoV activity. Dasabuvir (DSB), an anti-hepatitis C virus agent, was found to inhibit HuNoV infection in HIEs at micromolar concentrations. Dasabuvir also inhibited SARS-CoV-2 and human rotavirus A (RVA) infection in HIEs, highlighting the usefulness of the HIE platform for screening antiviral agents against various viruses targeting the intestines.
Paper Details　
Original Abstract of the Article :
Human noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups, yet no approved vaccines and drugs to treat HuNoV infection are available. In this study, we screened an antiviral compound library to identify compound(s) showing anti-HuNoV activity using a human intes...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565515/

データ提供：米国国立医学図書館（NLM）

Dasabuvir: A Potential Weapon Against Norovirus

The world of [viral gastroenteritis] is dominated by [human noroviruses (HuNoVs)], a group of [highly contagious pathogens] that cause [acute illness] in [people of all ages]. This study explores the potential of [dasabuvir] as a [novel anti-HuNoV inhibitor], using a [human intestinal enteroid (HIE) culture system] to evaluate its antiviral activity. The researchers screened a [compound library] to identify potential [anti-HuNoV drug candidates], and their findings suggest that [dasabuvir] shows promise as a therapeutic agent for [HuNoV infection].

Dasabuvir's Antiviral Potential

This study demonstrates that [dasabuvir], which is already used to treat [hepatitis C virus], has [inhibitory activity against HuNoVs] at [micromolar concentrations]. The researchers also found that [dasabuvir] was effective against [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human rotavirus A (RVA)], highlighting its potential as a broad-spectrum antiviral agent. This discovery opens new possibilities for developing effective treatments for [viral gastroenteritis], particularly in the absence of currently approved vaccines or drugs.

Combating Viral Infections: A New Frontier

The findings of this study offer a glimmer of hope in the fight against [viral gastroenteritis]. [Dasabuvir] has shown promise as a [potential antiviral drug] for [HuNoVs], but further research is needed to determine its safety and efficacy in humans. The development of effective treatments for [viral infections] is crucial for protecting public health and well-being, and this study provides a valuable stepping stone in that direction.

Dr. Camel's Conclusion

Just like a camel traverses the desert seeking water, researchers are tirelessly searching for effective treatments for [viral infections]. This study provides a promising oasis, highlighting the potential of [dasabuvir] to combat [HuNoV infection]. While further research is needed, it offers a beacon of hope in the ongoing battle against these debilitating pathogens.

Date :
  1. Date Completed 2022-01-05
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

34730374

DOI: Digital Object Identifier

PMC8565515

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PICO Info
in preparation
Languages

English

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