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Crystal nephropathy and amoxicillin: insights from international spontaneous reporting systems.

Author: CapelliIrene, De PontiFabrizio, FusaroliMichele, GattiMilo, PoluzziElisabetta, RaschiEmanuel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amoxicillin may be associated with crystal nephropathy, especially in France, particularly with intravenous administration of doses exceeding 12 g/day. Clinicians should monitor patients for early acute kidney injury (AKI).
Paper Details　
Original Abstract of the Article :
BACKGROUND: A substantial increase in amoxicillin-induced crystal nephropathy was recently reported in France. Our study aims to further characterize this safety issue from a worldwide perspective. METHODS: We queried both the FDA Adverse Event Reporting System (FAERS) and the Eudravigilance databa...See full text at original site
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引用元：
https://doi.org/10.1007/s40620-021-01191-y

データ提供：米国国立医学図書館（NLM）

Amoxicillin and Crystal Nephropathy: A Global Perspective

The kidneys, like a vital desert oasis, play a crucial role in maintaining our health. This study examines the potential link between amoxicillin, a commonly prescribed antibiotic, and crystal nephropathy, a condition involving the formation of crystals in the kidneys. The research, drawing data from international spontaneous reporting systems, found an increased reporting of crystal nephropathy associated with amoxicillin use, particularly in France. The study highlights the need for careful monitoring of patients receiving high doses of intravenous amoxicillin, particularly those at risk for developing crystal nephropathy.

Navigating the Landscape of Medication Safety: A Global Concern

The study's findings, like discovering a hidden spring in a seemingly barren desert, highlight the importance of global collaboration in medication safety surveillance. The increased reporting of crystal nephropathy associated with amoxicillin use, particularly in France, underscores the need for continued vigilance and data sharing to ensure the safety of medications worldwide.

Preventing Kidney Complications: A Collaborative Effort

This research emphasizes the importance of understanding the potential side effects of medications and the need for careful monitoring of patients. By working together, healthcare providers, researchers, and regulatory agencies can ensure the safe and effective use of medications, protecting the health of individuals around the globe.

Dr. Camel's Conclusion

This study serves as a reminder that medication safety is a global concern, requiring a collaborative approach to ensure the well-being of individuals worldwide. The increased reporting of crystal nephropathy associated with amoxicillin use highlights the need for careful monitoring and data sharing to protect the health of patients and ensure the safe use of medications. By working together, we can create a safer and healthier world for all.

Date :
  1. Date Completed 2022-04-12
  2. Date Revised 2022-06-12
Further Info :

Pubmed ID

34762277

DOI: Digital Object Identifier

10.1007/s40620-021-01191-y

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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