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Establishment of a rotavirus-infected zebrafish model and its application in drug screening.
Author: ChenJiabo, ChenYang, DaiGuiqin, FengYuxuan, LiFeng, SongLijun, ZhaoWenchang, ZhouYujing, ZhuXuemei
Original Abstract of the Article :
Rotavirus (RV) is one of the main pathogens that induce infantile diarrhea and by now no effective drugs are available for RV-induced infantile diarrhea. Thus the development of novel models is of vital importance for the pathological research of RV-induced infantile diarrhea, as well as the progres...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.biopha.2021.112398
データ提供:米国国立医学図書館(NLM)
Zebrafish: A Desert Oasis for Rotavirus Research
Rotavirus, a common cause of infantile diarrhea, is a formidable foe. This research, like a team of scientists exploring a new desert landscape, investigates the potential of zebrafish as a model system for studying rotavirus infection. The researchers sought to develop a reliable and robust model for testing antiviral drugs and understanding the mechanisms of rotavirus infection.
Zebrafish Model: A New Oasis in the Rotavirus Desert
This research introduces a novel rotavirus-infected zebrafish model, like a newly discovered oasis in the desert, for studying this infectious disease. The researchers found that zebrafish larvae could be infected with rotavirus, showing signs of diarrhea, altered survival rates, and inflammation, mimicking the clinical symptoms seen in infants. This model also proved useful for evaluating antiviral drugs, demonstrating its potential as a high-throughput platform for drug screening.
Protecting Infants: A Desert Oasis of Knowledge
This study provides a valuable new tool for rotavirus research, offering a reliable and efficient model for studying the virus and testing new drugs. As we continue to explore the desert of infectious diseases, understanding the mechanisms of rotavirus infection and developing new treatments is crucial for protecting infants from this debilitating illness.
Dr.Camel's Conclusion
The desert of rotavirus research is vast and complex, but this study offers a promising new avenue for exploration. The zebrafish model, like a refreshing oasis in the desert, provides a valuable tool for studying the virus and developing new treatments. By embracing innovative models and approaches, we can continue to navigate the desert of infectious diseases and find new solutions for protecting vulnerable populations.
Date :
- Date Completed 2022-03-14
- Date Revised 2022-03-14
Further Info :
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