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Fatal case of delayed-onset haemolytic anaemia after oral artemether-lumefantrine.

Author: GustafssonLotta, JamesSunil, ThozhuthumparambilKarunakaran Pradeep, ZhangYimeng

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Postartemisinin delayed haemolysis (PADH) is a known complication of artemisinin-based antimalarial treatments, leading to severe anemia. This report describes the first documented fatal case of PADH, highlighting the importance of post-treatment monitoring and careful consideration of treatment options, especially when access to blood products is limited or refused.
Paper Details　
Original Abstract of the Article :
Artemisinin derivatives are used globally in the management of falciparum malaria. Postartemisinin delayed haemolysis (PADH) is a recognised adverse event contributing to severe anaemia. To the best of our knowledge, we report the first recorded fatal case of PADH. A 60-year-old woman presented with...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606760/

データ提供：米国国立医学図書館（NLM）

Artemisinin Derivatives: A Double-Edged Sword in Malaria Treatment

Artemisinin derivatives are crucial weapons in the fight against malaria, but their use comes with potential complications. This case report highlights the risk of postartemisinin delayed haemolysis (PADH), a serious adverse event that can lead to severe anaemia. The researchers describe a fatal case of PADH in a 60-year-old woman who had recently been treated for uncomplicated falciparum malaria with artemether-lumefantrine, emphasizing the importance of post-treatment monitoring and careful consideration of the potential risks associated with this medication.

Fatal Case of PADH: A Reminder of the Risks

This case report serves as a stark reminder that even seemingly safe medications can have serious and potentially fatal side effects. The patient's experience underscores the importance of careful patient selection, close monitoring, and a thorough understanding of the potential risks associated with artemisinin derivatives. This knowledge is crucial for ensuring the safety and well-being of patients receiving treatment for malaria.

Navigating the Malaria Treatment Desert: A Look at Artemisinin Derivatives

This case report highlights the complex and sometimes unpredictable nature of drug treatment. The research underscores the importance of careful consideration of the potential risks and benefits of using artemisinin derivatives, particularly in patients who may be at increased risk for PADH. This information is essential for making informed decisions about medication choices and ensuring the safety of patients.

Dr. Camel's Conclusion

This case report is a harsh reminder of the potential dangers of using artemisinin derivatives. The patient's tragic experience underscores the importance of careful patient selection, close monitoring, and a thorough understanding of the potential risks and benefits of these medications.

Date :
  1. Date Completed 2021-11-23
  2. Date Revised 2023-11-20
Further Info :

Pubmed ID

34799392

DOI: Digital Object Identifier

PMC8606760

Related Literature

Article Analysis
・Effects of artemether and lumefantrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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