Evaluation of the Pharmacokinetic Interaction and Safety of Ubrogepant Coadministered With Esomeprazole Magnesium.

Author: BoinpallyRamesh, LuKaifeng

Paper Details 
Original Abstract of the Article :
Ubrogepant is a calcitonin gene-related peptide receptor antagonist for the acute treatment of migraine. Esomeprazole magnesium increases intragastric pH, which may affect oral ubrogepant absorption. This open-label, nonrandomized, crossover trial evaluated esomeprazole magnesium's impact on the pha...See full text at original site
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引用元:
https://doi.org/10.1002/cpdd.1034

データ提供:米国国立医学図書館(NLM)

Ubrogepant and Esomeprazole Magnesium: A Look at Drug Interactions

The world of

migraine

treatment is constantly evolving, with researchers seeking new and effective therapies to manage this debilitating condition. This study examines the potential interactions between ubrogepant, a drug used to treat migraine, and esomeprazole magnesium, a medication used to reduce stomach acid. The researchers conducted a clinical trial to assess the impact of esomeprazole magnesium on the pharmacokinetics of ubrogepant. They found that while esomeprazole magnesium can slightly reduce the absorption of ubrogepant, this effect is not considered clinically significant.

Navigating Drug Interactions: Ensuring Safety and Effectiveness

This study offers valuable insights into the potential interactions between ubrogepant and esomeprazole magnesium, two commonly used medications. The researchers found that while there is a minor interaction, it does not significantly impact the effectiveness of ubrogepant. This is like a desert traveler who encounters a slight detour on their journey, but it doesn’t alter the overall destination or disrupt the travel plans. The study reassures us that these medications can be safely used together, providing peace of mind for patients.

Understanding Drug Interactions: A Crucial Component of Safe and Effective Care

This study underscores the importance of understanding drug interactions in healthcare. While minor interactions may not always be clinically significant, it is crucial to be aware of these possibilities and to monitor patients carefully to ensure optimal safety and effectiveness of treatment. This is like a desert traveler who carefully observes the terrain, anticipating potential obstacles and adjusting their route accordingly. By understanding drug interactions, we can ensure that patients receive the best possible care and achieve the desired treatment outcomes.

Dr.Camel's Conclusion

This study highlights the importance of carefully considering drug interactions, even when the impact may be minor. It’s like a desert traveler who must be mindful of the shifting sands, even when the path seems clear. By understanding the potential interactions between medications, we can make informed decisions about treatment and ensure the safety and effectiveness of care for patients.

Date :
  1. Date Completed 2022-04-04
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34811955

DOI: Digital Object Identifier

10.1002/cpdd.1034

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Languages

English

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