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Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus.
Author: AlencarEverton N, Amaral-MachadoLucas, AraújoFábio A C, CostaMoan J F, Sette-DE-SouzaPedro Henrique
Original Abstract of the Article :
Influenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1590/0001-3765202120210964
データ提供:米国国立医学図書館(NLM)
Phytocompounds from Schinopsis brasiliensis: Potential Antiviral Agents Against Influenza A
The search for effective antiviral therapies against influenza A virus is as challenging as traversing a vast and unforgiving desert. This study investigated the antiviral potential of two phytocompounds, syringaresinol and cycloartenone, derived from the bark of Schinopsis brasiliensis, a tree native to South America. The researchers employed in silico approaches to evaluate the binding affinities of these compounds to key proteins involved in influenza A virus replication.
Promising Antiviral Activity of Phytocompounds
The study found that both syringaresinol and cycloartenone exhibited promising in silico antiviral activity against several influenza A proteins, including neuraminidase, polymerase basic protein 2, hemagglutinin, and the M2 ion channel protein. These findings, like a hidden oasis in the desert, offer a glimmer of hope for developing new antiviral therapies from natural sources.
Exploring Natural Antiviral Agents
This research, much like a desert expedition revealing hidden treasures, highlights the potential of natural products for combating viral infections. The study suggests that syringaresinol and cycloartenone warrant further investigation as potential antiviral agents, potentially paving the way for new and effective therapies for influenza A infection.
Dr.Camel's Conclusion
This study, like a camel caravan carrying valuable resources across the desert, offers a promising approach for combating influenza A virus. The findings suggest that syringaresinol and cycloartenone, derived from a natural source, exhibit significant antiviral activity, paving the way for the development of novel and potentially safer therapies for influenza A infection.
Date :
- Date Completed 2021-11-25
- Date Revised 2021-11-25
Further Info :
Related Literature
English
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