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[Angiogenesis inhibitors: mechanism of action and nephrotoxicity].

Author: ClouEmmanuelle, LuqueYosu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tumoral angiogenesis, the formation of new blood vessels that support tumor growth, is a key target for cancer treatment. This article reviews the mechanisms of action and potential toxicities, particularly renal, of angiogenesis inhibitors targeting the Vascular Endothelial Growth Factor (VEGF) pathway. The review focuses on the side effects of VEGF inhibitors, including bevacizumab and tyrosine kinase inhibitors like sunitinib and sorafenib, highlighting the need for careful monitoring to manage potential renal complications.
Paper Details　
Original Abstract of the Article :
Tumoral angiogenesis is a key mechanism involved in the growth and spread of cancer cells. The development of angiogenesis inhibitors, particularly those targeting the Vascular Endothelial Growth Factor (VEGF) pathway, has improved the prognosis and survival of many cancer patients since they were a...See full text at original site
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引用元：
https://doi.org/10.1016/j.nephro.2021.08.004

データ提供：米国国立医学図書館（NLM）

Angiogenesis Inhibitors: A Look at Their Action and Potential Kidney Problems

This research dives deep into the world of [Angiogenesis inhibitors] and their impact on [Cancer treatment]. The study uses [Clinical trials and observation] to explore [How angiogenesis inhibitors work and their side effects]. The authors discovered that [Angiogenesis inhibitors can improve cancer survival but also carry the risk of kidney problems]. A key finding is that [The prescribing doctor should monitor for potential kidney damage during treatment].

The Double-Edged Sword of Angiogenesis Inhibitors

The results suggest that [Angiogenesis inhibitors are effective in combating cancer but require careful monitoring to avoid potential kidney complications]. While they offer a beacon of hope for cancer patients, it's crucial to be aware of the possible side effects.

Keeping Your Kidneys Healthy While Fighting Cancer

If you're undergoing treatment with angiogenesis inhibitors, it's essential to work closely with your doctor for regular checkups. They can monitor your kidney function and adjust treatment if necessary. Remember, taking care of your kidneys is an important part of maintaining overall health during cancer treatment.

Dr. Camel's Conclusion

This research is a valuable reminder that every treatment, even those with life-saving potential, comes with its own set of challenges. It's like navigating a vast desert - we need to be prepared for both the scorching sun and the unexpected oasis. Just as a camel adapts to survive the harshest conditions, we must be mindful of the potential side effects of medications and work closely with our healthcare providers to ensure our well-being.
Date :
  1. Date Completed 2022-02-10
  2. Date Revised 2022-02-10
Further Info :

Pubmed ID

34838486

DOI: Digital Object Identifier

10.1016/j.nephro.2021.08.004

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in preparation
Languages

French

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