Paper Details 
Original Abstract of the Article :
The present work aims to investigate the antiparasitic and the immunomodulating effects of nitazoxanide (NTZ) and ivermectin (IVC) alone or combined together or combined with selenium (Se), on Cryptosporidium infection in diabetic mice. The results revealed that the combined NTZ and IVC therapy achi...See full text at original site
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引用元:
https://doi.org/10.1590/S1984-29612021087

データ提供:米国国立医学図書館(NLM)

Combating Cryptosporidium Infection in Diabetic Mice: A Quest for Effective Therapies

Cryptosporidium infection, a parasitic disease that can cause severe gastrointestinal distress, poses a particular challenge for individuals with diabetes. This study, published in the journal *[Journal Name]*, investigates the efficacy of different antiparasitic treatments for Cryptosporidium infection in diabetic mice. The study explored the antiparasitic and immunomodulating effects of nitazoxanide (NTZ), ivermectin (IVC), and selenium (Se), both individually and in combination, aiming to identify effective treatment strategies for this challenging condition.

A Multifaceted Approach to Cryptosporidium Infection

The study revealed that a combined therapy of NTZ and IVC achieved the highest reduction in fecal oocysts, demonstrating a synergistic effect that could potentially translate into improved outcomes for patients. The study also found that adding Se to either NTZ or IVC further enhanced oocyst reduction, suggesting the potential benefits of a multifaceted approach. The study also observed significant improvements in intestinal histopathology and a restored balance in the CD4/CD8 T cell ratio following therapy, indicating a positive impact on both the immune system and intestinal health.

Hope for a Brighter Future for Diabetic Patients

This study provides encouraging evidence for the potential of combined antiparasitic therapies, such as NTZ and IVC, to effectively manage Cryptosporidium infection in diabetic patients. The study's findings highlight the importance of ongoing research to identify the most effective treatment strategies and improve the management of this challenging condition in susceptible populations.

Dr. Camel's Conclusion

The desert of Cryptosporidium infection can be a formidable adversary for individuals with diabetes. This study offers a glimmer of hope, highlighting the potential of combined therapies to effectively combat this parasitic infection. The findings underscore the importance of seeking innovative and multifaceted approaches to manage this challenging condition, providing a path towards a brighter future for diabetic patients.

Date :
  1. Date Completed 2021-12-03
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

34852131

DOI: Digital Object Identifier

10.1590/S1984-29612021087

Related Literature

SNS
PICO Info
in preparation
Languages

English

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