Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer.

Author: , Avall-LundqvistElisabeth, ClasseJean-Marc, FerronGwenael, Ghaem-MaghamiSadaf, GreggiStefano, GuyonFrédéric, HarterPhilipp, HasenburgAnnette, HillemannsPeter, HilpertFelix, JensenPernille, KimJae-Weon, KristensenGunnar, LundBente, LécuruFabrice, MeierWerner, MirzaMansoor R, MosgaardBerit J, OlaitanAdeola, PomelChristophe, PonceJordi, RaspagliesiFrancesco, ReinthallerAlexander, ReussAlexander, SantaballaAna, SehouliJalid, SelleFrederic, VergoteIgnace, ZangRongyu, du BoisAndreas

Paper Details 
Original Abstract of the Article :
BACKGROUND: Treatment for patients with recurrent ovarian cancer has been mainly based on systemic therapy. The role of secondary cytoreductive surgery is unclear. METHODS: We randomly assigned patients with recurrent ovarian cancer who had a first relapse after a platinum-free interval (an interva...See full text at original site
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引用元:
https://doi.org/10.1056/NEJMoa2103294

データ提供:米国国立医学図書館(NLM)

A Second Chance: Cytoreductive Surgery for Relapsed Ovarian Cancer

The treatment of ovarian cancer is like navigating a vast desert: there are often challenges and setbacks along the way. This study explores a novel approach to managing recurrent ovarian cancer, focusing on the potential benefits of secondary cytoreductive surgery. The researchers, like explorers seeking a new path, investigated whether this surgical intervention could improve the survival rates of patients.

The study randomly assigned patients with recurrent ovarian cancer to undergo secondary cytoreductive surgery followed by platinum-based chemotherapy or to receive platinum-based chemotherapy alone. The primary outcome of interest was overall survival. The results were encouraging: patients who underwent cytoreductive surgery experienced a statistically significant increase in overall survival compared to those who received chemotherapy alone. The greatest benefit was observed in patients who achieved a complete resection during surgery, suggesting that the extent of surgical intervention plays a crucial role in determining outcomes.

Hope for Patients with Recurrent Ovarian Cancer

This research provides a glimmer of hope for patients with recurrent ovarian cancer. The study's findings demonstrate the potential of cytoreductive surgery to prolong survival, offering a valuable option for patients who have experienced a relapse. The positive impact of complete resection highlights the importance of meticulous surgical techniques and careful patient selection.

Empowering Patients with Options

This study underscores the importance of offering patients comprehensive treatment options tailored to their individual needs and circumstances. Just as a camel adapts to the desert's diverse terrain, patients with ovarian cancer may benefit from different treatment strategies. This research provides valuable insights into the potential of cytoreductive surgery, empowering healthcare providers to make informed decisions about treatment plans for their patients.

Dr. Camel's Conclusion

This study is like a beacon of hope shining through the desert of ovarian cancer treatment. It provides evidence that cytoreductive surgery, when carefully considered and executed, can significantly improve survival rates for patients with recurrent ovarian cancer. As a researcher who has witnessed the struggles of patients with this disease, I am encouraged by the possibility of extending life and enhancing quality of life through this promising surgical intervention. This research serves as a reminder that even in the face of adversity, there is always hope for finding new paths to healing and recovery.

Date :
  1. Date Completed 2021-12-27
  2. Date Revised 2022-05-27
Further Info :

Pubmed ID

34874631

DOI: Digital Object Identifier

10.1056/NEJMoa2103294

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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