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The pharmacokinetic study of Tanreqing and the interaction with cefixime in rat model of pneumonia by validated UPLC-MS/MS.
Author: DongHao-Ran, FengSu-Xiang, LiJian-Sheng, LiuXue-Fang, TianYan-Ge, ZhaoDi
Original Abstract of the Article :
Combining traditional Chinese medicine and chemical drugs with antimicrobial activities has become more popular, but there is insufficient relevant research on such combinations. The Tanreqing injection (TRQI), a Chinese compound medicine, exhibits therapeutic effects in treating upper respiratory t...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.jpba.2021.114484
データ提供:米国国立医学図書館(NLM)
Unveiling the Desert of Drug Interactions: Tanreqing and Cefixime
The combination of [traditional Chinese medicine (TCM)] and conventional drugs is an increasingly popular approach, much like a caravan drawing upon the wisdom of seasoned guides and the tools of modern navigation. This study, like a research team exploring the complex interactions between TCM and Western medicine, investigates the pharmacokinetic interactions of [Tanreqing injection (TRQI)] and [cefixime] in a rat model of pneumonia. The research seeks to understand how these two drugs interact in the body, potentially offering insights into the safety and efficacy of this combination.
A Sandstorm of Uncertainty: The Complexities of Drug Interactions
This research, like a caravan encountering a sudden sandstorm in the desert, reveals the complexities of drug interactions. The findings indicate that [co-administration of TRQI and cefixime] can significantly alter the pharmacokinetic parameters of key components of TRQI. This discovery, like a shifting landscape in the desert, highlights the need for caution when combining TCM and Western drugs, as their interactions can be unpredictable.
Navigating the Unknowns: The Importance of Careful Monitoring
This research, like a map highlighting potential hazards in a desert, underscores the importance of careful monitoring when combining [TCM and Western drugs]. The findings indicate that the interactions between [TRQI and cefixime] can be complex and potentially unpredictable. This highlights the need for further research and careful clinical evaluation before this combination can be widely recommended.
Dr.Camel's Conclusion
The research on the pharmacokinetic interactions of Tanreqing injection and cefixime provides a valuable cautionary tale, like a caravan encountering a hidden danger in the desert. This study highlights the complexities of drug interactions and the need for careful monitoring when combining TCM and Western drugs. Further research is essential to fully understand the potential risks and benefits of such combinations, ensuring the safety and efficacy of treatment for patients.
Date :
- Date Completed 2022-01-11
- Date Revised 2022-05-31
Further Info :
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