Benzalkonium Chloride-Induced Corneal Epithelial Injury in Rabbit Reduced by Rebamipide.

Author: FukudaMasamichi, IshidaHidetoshi, KuboEri, SasakiHiroshi, SekiYusuke, ShibataNaoko, SugiyamaKazuhisa, TakahashiNobuo, TakedaNobuo

Paper Details 
Original Abstract of the Article :
<b><i>Purpose:</i></b> We assessed the effect of rebamipide ophthalmic solution on corneal epithelial injury due to benzalkonium chloride (BAK) by fluorescein (FL) staining and corneal resistance (CR). <b><i>Methods:</i></b> After determining the absence of corneal epithelial damage by FL and CR, r...See full text at original site
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引用元:
https://doi.org/10.1089/jop.2021.0052

データ提供:米国国立医学図書館(NLM)

Protecting the Eye: Rebamipide's Role in Corneal Health

The delicate surface of the cornea, the transparent front part of the eye, is vulnerable to damage from various factors, including preservatives found in eye drops. This study explores the protective effects of rebamipide, an ophthalmic solution, against corneal epithelial injury caused by benzalkonium chloride (BAK), a commonly used preservative. The researchers conducted experiments on rabbits, comparing the effects of rebamipide to saline solution. They found that rebamipide significantly reduced the severity of BAK-induced corneal epithelial injury, as measured by corneal resistance and fluorescein staining.

Rebamipide: A Shield Against Corneal Damage

The study's findings highlight the protective effects of rebamipide against BAK-induced corneal epithelial injury. This discovery suggests that rebamipide could play a valuable role in protecting the cornea and maintaining its health, particularly for individuals who use eye drops containing BAK. The study emphasizes the need for further research to explore the long-term efficacy and safety of rebamipide in human patients.

A Oasis for Corneal Health

The cornea, like a delicate window to the world, requires careful protection from damage. This study offers a glimmer of hope in the form of rebamipide, a potential shield against BAK-induced corneal injury. The findings underscore the importance of developing safe and effective treatments to maintain corneal health and protect vision.

Dr.Camel's Conclusion

This research provides valuable insight into the protective effects of rebamipide against BAK-induced corneal epithelial injury. This discovery offers a potential solution for maintaining corneal health and protecting vision, particularly for individuals who use eye drops containing BAK. The study underscores the importance of developing safe and effective therapies to address the challenges of corneal health, ensuring that we can continue to see the world with clarity and beauty.

Date :
  1. Date Completed 2022-03-16
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

34936495

DOI: Digital Object Identifier

10.1089/jop.2021.0052

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SNS
PICO Info
in preparation
Languages

English

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