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Nitazoxanide and Cancer Drug Resistance: Targeting Wnt/β-catenin Signaling Pathway.

Author: AhmadvandHassan, Hemmati-DinarvandMohsen, SeghatoleslamAtefeh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nitazoxanide (NTZ) was investigated as a potential reversal agent for multidrug resistance (MDR) in colorectal cancer cells. NTZ combined with oxaliplatin (OXP) synergistically inhibited proliferation, induced apoptosis, and arrested cell cycle in LS174T and LS174T/OXP cell lines. These results suggest NTZ has potential for overcoming MDR in colorectal cancer treatment.
Paper Details　
Original Abstract of the Article :
One of the most important complications that lead to unsuccessful treatment of cancer is resistance against chemotherapy agents, so called multidrug resistance (MDR). Thus, identification of the novel medications with low side effects and high efficacy to reverse MDR is highly required. Accordingly,...See full text at original site
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引用元：
https://doi.org/10.1016/j.arcmed.2021.12.001

データ提供：米国国立医学図書館（NLM）

Nitazoxanide and Cancer Drug Resistance: A Camel's Quest for Effective Treatment

One of the biggest hurdles in cancer treatment is drug resistance, where cancer cells become impervious to the effects of chemotherapy drugs. This research investigates the potential of nitazoxanide (NTZ), a drug typically used for intestinal infections, to overcome drug resistance in cancer cells. The study focuses on the molecular mechanisms involved in drug resistance and explores how NTZ might reverse this resistance, potentially enhancing the effectiveness of chemotherapy.

The study examines the effects of NTZ in combination with oxaliplatin (OXP), a chemotherapy drug, in cancer cell lines. The research found that NTZ can potentially reverse drug resistance in cancer cells by targeting a specific signaling pathway called Wnt/β-catenin. This pathway plays a crucial role in regulating cell growth and survival, and by targeting it, NTZ could potentially restore the sensitivity of cancer cells to chemotherapy drugs.

The Desert of Drug Resistance: Finding a Path to Victory

Think of it like this: Drug resistance is like a vast and unforgiving desert, where cancer cells can evade the effects of chemotherapy drugs. This research explores the potential of NTZ to act like a guide, leading us through this challenging landscape and opening up new avenues for effective treatment. It's like discovering a hidden oasis that can replenish our resources and give us a renewed chance to fight against cancer.

A Camel's Advice for Cancer Patients

This research highlights the ongoing quest for more effective and personalized cancer treatments. If you're facing cancer, it's crucial to consult with a doctor to discuss the best treatment options available and to explore the potential benefits and risks associated with different approaches. Remember, there is hope, and researchers continue to seek new and innovative ways to fight this disease.

Dr. Camel's Conclusion

This research offers a glimmer of hope in the battle against cancer drug resistance. It highlights the importance of exploring new drug combinations and innovative approaches to overcome this formidable challenge. As we continue to navigate the desert of cancer research, it's essential to remain optimistic and to support the ongoing search for more effective and personalized treatments for all those affected by this disease.

Date :
  1. Date Completed 2022-04-27
  2. Date Revised 2022-05-25
Further Info :

Pubmed ID

34937659

DOI: Digital Object Identifier

10.1016/j.arcmed.2021.12.001

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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