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Effects of Multimodal Analgesic Protocol, with Buprenorphine and Meloxicam, on Mice Well-Being: A Dose Finding Study.

Author: FurumotoKayo, ItoiTakamasa, KamisakaTomomi, KandaTeppei, KawasumiAsami, MaetaNoritaka, NoharaMasakatsu, OgitaKumi, SaekiKaori, TakataKoushi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A multimodal analgesic protocol using buprenorphine and meloxicam was evaluated in mice to assess its impact on well-being during the perioperative period. Although the protocol was expected to have an analgesic effect on pain associated with laparotomy, it did not prevent food intake and weight decrease in mice. These findings suggest that additional interventions beyond analgesia are needed to minimize negative side effects and optimize postoperative recovery in mice.
Paper Details　
Original Abstract of the Article :
The anesthetic or analgesic agent of choice, route and frequency of anesthetic or analgesic administration, and stressors induce distress during the perioperative period. We evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. Twenty-four Slc:ICR mal...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698195/

データ提供：米国国立医学図書館（NLM）

Multimodal Analgesia in Mice: A Camel's Journey Through Perioperative Pain Management

Imagine a camel traversing a rocky desert terrain. The journey can be fraught with discomfort, just as a mouse undergoing surgery can experience significant pain. This study investigates the effectiveness of a multimodal analgesic protocol using buprenorphine and meloxicam in mice.

Pain Management in the Desert: A Camel's Insights

This research evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. The study found that this protocol, while effective in reducing pain associated with laparotomy, did not completely alleviate other negative side effects, such as decreased food intake and weight loss.

Understanding the Landscape of Pain: A Camel's Advice

This study emphasizes the importance of a comprehensive approach to [perioperative pain management] in animal models. It's a reminder that the desert of pain is complex, and we must consider all aspects of the patient's well-being, not just the pain itself, when designing effective treatment strategies.

Dr. Camel's Conclusion

This research highlights the need for further investigation into multimodal analgesic protocols for mice. It's a reminder that the quest for effective pain management strategies in animal models is ongoing, and we must continue to explore new approaches to minimize the suffering of our animal companions.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-12-28
Further Info :

Pubmed ID

34944198

DOI: Digital Object Identifier

PMC8698195

Related Literature

Article Analysis
・Effects of meloxicam・Side Effects of meloxicam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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