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Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury.

Author: GaoYouhe, HengZiqi, HuanYuhang, JiaLulu, WeiJing, YuYuncui, ZhaoChenyang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Statins are commonly used medications to lower cholesterol, but they can cause muscle symptoms (SAMS) in some patients. This study investigated urine proteome changes associated with SAMS in a rat model. Urine proteome analysis revealed changes in proteins related to muscle damage and the pathogenesis of SAMS, suggesting urine could be a potential source for monitoring drug side effects.
Paper Details　
Original Abstract of the Article :
Statin-associated muscle symptoms (SAMS) are the main side effects of statins. Currently, there are no effective biomarkers for accurate clinical diagnosis. Urine is not subject to homeostatic control and therefore accumulates early changes, making it an ideal biomarker source. We therefore examined...See full text at original site
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引用元：
https://doi.org/10.1016/j.jprot.2021.104477

データ提供：米国国立医学図書館（NLM）

Unraveling the Mysteries of Statin-Associated Muscle Symptoms: A Look at the Urinary Proteome

Statin-associated muscle symptoms (SAMS) are a common side effect of statins, like a desert traveler experiencing fatigue and muscle cramps after a long trek. This study investigates the changes in the urinary proteome of rats treated with simvastatin, hoping to uncover potential biomarkers for early detection and diagnosis of SAMS.

Mapping the Desert of Muscle Injury: Exploring the Urinary Proteome

The researchers examined the urine proteome of rats with SAMS over time, analyzing changes in protein levels. This is like using a map to trace the path of a sandstorm, observing the changes in the landscape as the storm progresses. The results revealed specific changes in proteins associated with muscle damage, metabolism, and apoptosis, potentially providing valuable clues for early detection and intervention.

Finding the Oasis of Hope: Potential Biomarkers for Early Diagnosis

The study identifies several proteins in urine that are linked to SAMS, potentially serving as biomarkers for early diagnosis. This is like finding a hidden oasis in the desert, providing a vital source of water and resources. These findings offer a promising avenue for developing non-invasive methods for monitoring drug side effects and improving patient care.

Dr. Camel's Conclusion

This study sheds light on the potential of urinary proteomics to unravel the mysteries of statin-associated muscle symptoms. The findings offer promising leads for developing novel biomarkers for early detection and diagnosis, paving the way for more effective management of drug side effects. It is like finding a new path through the desert of medical research, leading us closer to a better understanding of complex conditions and improving patient outcomes.
Date :
  1. Date Completed 2022-02-28
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34990819

DOI: Digital Object Identifier

10.1016/j.jprot.2021.104477

Related Literature

Article Analysis
・Side Effects of simvastatin
SNS
PICO Info
in preparation
Languages

English

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