Memantine augmentation of sertraline in the treatment of symptoms and executive function among patients with obsessive-compulsive disorder: A double-blind placebo-controlled, randomized clinical trial.

Author: AskariSanaz, MokhtariSaba, ShalbafanMohammadreza, ShariatSeyed Vahid, ShariatiBehnam, YarahmadiMasoomeh

Paper Details 
Original Abstract of the Article :
Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually decrease the severity of the symptoms by 20-30%; however, 40-60% of OCD patients do not achieve a satisfactory response. Our main objective was to investigate the effectiveness of memantine, a non-comp...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753835/

データ提供:米国国立医学図書館(NLM)

Memantine Augmentation for OCD Treatment: A Double-Blind Trial

The field of mental health constantly seeks new strategies to alleviate the burden of obsessive-compulsive disorder (OCD). This research investigates the potential benefits of memantine, a medication that targets NMDA receptors, as an adjunct therapy to sertraline, a commonly prescribed SSRI, for OCD treatment. Employing a double-blind, placebo-controlled, randomized clinical trial, the authors aimed to assess the impact of memantine on symptom severity and executive function in OCD patients. This study provides valuable insights into the potential of memantine as a novel treatment approach for OCD. The findings highlight the need for further investigation into the role of NMDA receptor modulation in OCD.

Memantine Shows Promise as an Adjunct Therapy for OCD

The study suggests that memantine, when combined with sertraline, could improve symptom severity and executive function in OCD patients. While the findings are encouraging, more research is needed to confirm these results and establish the optimal dosage and treatment duration for memantine in OCD.

Exploring New Treatment Options for OCD

This research contributes to the growing body of knowledge on the potential of memantine for treating OCD. The findings suggest that exploring novel therapeutic approaches that target specific brain pathways may lead to improved outcomes for individuals with OCD. It reminds us that the quest for effective treatment options for OCD is a continuous journey.

Dr.Camel's Conclusion

Imagine a camel traversing a vast desert, seeking solace from the relentless heat. This research is like a refreshing oasis, offering hope and a potential path to healing for those struggling with OCD. Memantine's ability to modulate NMDA receptors, a key player in brain function, could be a game changer for OCD treatment. This research is a testament to the relentless pursuit of better therapies in the field of mental health.

Date :
  1. Date Completed 2022-03-10
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

35022014

DOI: Digital Object Identifier

PMC8753835

SNS
PICO Info
in preparation
Languages

English

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