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Drug delivery to the intestinal lymph by oral formulations.

Author: KojimaHiroyuki, KondoHiromu, SakoKazuhiro, YoshidaTakayuki

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Oral drug delivery systems (DDS) targeting lymphocytes in the intestinal lymphatic vessels, ducts, and nodes offer a promising approach for treating various diseases. Lipid-based DDS, such as those containing triglycerides and fatty acids, can deliver drugs to the lymph via the chylomicron pathway. This allows for reduced drug doses and potentially fewer systemic side effects.
Paper Details　
Original Abstract of the Article :
Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases. The intestinal lymph harbors numerous lymphocyte subsets, and DDS containing lipids such as triglycerides and fatty acids can deliver drugs to the lymph ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1080/10837450.2022.2030353

データ提供：米国国立医学図書館（NLM）

Delivering Drugs to the Intestinal Lymph: A New Pathway

The lymphatic system, like a hidden river flowing through the body, plays a vital role in immunity and drug delivery. This research explores the potential of oral drug delivery systems (DDS) that target the intestinal lymph, a promising strategy for treating a variety of diseases. It's like finding a secret passageway through the desert that leads to a hidden oasis, allowing for more efficient and targeted drug delivery.

Lipid Formulations: A Key to Lymphatic Delivery

The authors review various lipid-based formulations, including micro/nanoemulsions and liposomes, that can effectively deliver drugs to the intestinal lymph. These formulations act as 'caravans,' carrying drugs through the lymphatic system, potentially reducing systemic adverse effects and improving therapeutic efficacy.

Potential for Minimizing Side Effects

This research suggests that targeting drug delivery to the intestinal lymph can lead to a more targeted approach, reducing the amount of medication needed and minimizing systemic side effects. This is like finding a shortcut through the desert, allowing travelers to reach their destination more efficiently and safely.

Dr. Camel's Conclusion

Exploring innovative drug delivery systems that target the lymphatic system is like discovering a new path in the desert. This research offers exciting possibilities for improving drug therapy, potentially leading to more effective treatments and reduced side effects. The future of drug delivery is an exciting journey, and we, as researchers, are constantly searching for new and better ways to improve patient care.

Date :
  1. Date Completed 2022-04-29
  2. Date Revised 2022-04-29
Further Info :

Pubmed ID

35037843

DOI: Digital Object Identifier

10.1080/10837450.2022.2030353

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English

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