Paper Details

  1. Home
  2. Paper Details

Critical Appraisal of Large Vitamin D Randomized Controlled Trials.

Author: GrüblerMartin R, KarrasSpyridon N, MärzWinfried, OdlerBalazs, PilzStefan, Theiler-SchwetzVerena, TrummerChristian, VerheyenNicolas D, ZittermannArmin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

While vitamin D is important for bone health, research on its benefits for other conditions, like cancer, heart disease, and overall survival, has been mixed. Many recent studies on vitamin D have included people who weren't deficient, and some even gave moderate doses of vitamin D to the control groups. These studies haven't found strong evidence for these benefits, but some smaller studies and analyses suggest possible benefits, like reduced cancer death and fewer infections. Large doses of vitamin D haven't been shown to be unsafe in most people, except for those who are very sick or take very high doses infrequently. Future research should focus on people with vitamin D deficiency or who are likely to benefit from vitamin D and use more personalized approaches to treatment.
Paper Details　
Original Abstract of the Article :
As a consequence of epidemiological studies showing significant associations of vitamin D deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular diseases, cancer, and mortality, large vitamin D randomized controlled trials (RCTs) have been designed and conduct...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778517/

データ提供：米国国立医学図書館（NLM）

Vitamin D and Its Role in Health: A Critical Appraisal of Large Randomized Controlled Trials

The [nutritional role of vitamin D] has been a subject of intense research in recent years. Numerous epidemiological studies have linked vitamin D deficiency to a variety of health problems, including cardiovascular diseases, cancer, and mortality. To further investigate these connections, researchers have conducted large-scale [randomized controlled trials (RCTs)], which are considered the gold standard for evaluating the efficacy of treatments.

The Limitations of Large-Scale Trials

This study critically examines the findings of these large-scale RCTs. The authors point out that many of these trials did not restrict their study populations to individuals with vitamin D deficiency, and some even allowed moderate supplementation in the placebo groups. Consequently, the results have been inconclusive, with no significant effects observed on primary outcomes such as cancer, cardiovascular events, and mortality. However, exploratory analyses and meta-analyses have suggested potential benefits, such as reductions in cancer mortality or acute respiratory infections.

Navigating the Complexities of Vitamin D Research

The authors emphasize the need for more personalized approaches in future vitamin D research. They advocate for focusing on populations with vitamin D deficiency or those with specific characteristics that might indicate a high sensitivity to treatment. Furthermore, they call for the development of more targeted interventions, tailored to individual needs and risk factors.

Dr.Camel's Conclusion

Vitamin D research is like a desert oasis—promising a vital source of health benefits, but requiring careful exploration to understand its true potential. This study highlights the need for rigorous research methods and a personalized approach to maximize the benefits of vitamin D while minimizing potential risks.

Date :
  1. Date Completed 2022-01-28
  2. Date Revised 2022-01-28
Further Info :

Pubmed ID

35057483

DOI: Digital Object Identifier

PMC8778517

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.