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The Effect of Acid Suppression Therapy on the Safety and Efficacy of Plecanatide: Analysis of Randomized Phase III Trials.

Author: FranklinHoward, MoshireeBaharak, RezaieAli, SchoenfeldPhilip

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This analysis investigates the efficacy and safety of plecanatide in adults with chronic idiopathic constipation (CIC) when combined with acid suppression therapy.
Paper Details　
Original Abstract of the Article :
Plecanatide, an approved therapy for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation, is an analogue of uroguanylin that replicates its pH-sensitive activity and binds to guanylate cyclase-C receptors expressed on intestinal epithelium, stimulating fluid secretio...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinthera.2021.11.009

データ提供：米国国立医学図書館（NLM）

The Effect of Acid Suppression Therapy on Plecanatide: A Review of Clinical Trials

This research explores the potential interactions between acid suppression therapy and plecanatide, a drug used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Plecanatide is a unique drug that stimulates fluid secretion in the intestines, helping to relieve constipation. The study examines the effects of co-administration of acid suppression therapy on the efficacy and safety of plecanatide in adults with CIC.

Plecanatide: A Promising Treatment for Constipation, but with Potential Interactions

The researchers analyzed data from randomized Phase III clinical trials and found that the co-administration of acid suppression therapy did not significantly impact the efficacy or safety of plecanatide in adults with CIC. However, the study notes that more research is needed to fully understand the potential interactions between plecanatide and acid suppression therapy. It's like examining the complex interplay between different desert plants and their unique adaptations to the harsh environment.

Navigating the Complexities of Drug Interactions

This research highlights the importance of understanding potential drug interactions. While the study suggests that acid suppression therapy does not significantly impact the efficacy or safety of plecanatide, more research is needed to fully clarify this issue. It's like carefully navigating a complex desert ecosystem, ensuring that the interactions between different elements are well understood to avoid unintended consequences.

Dr. Camel's Conclusion

This research provides valuable insights into the potential interactions between plecanatide and acid suppression therapy. It's like exploring a vast and complex desert landscape, where the interactions between different elements can be both beneficial and potentially harmful. The study underscores the importance of ongoing research to fully understand the complexities of drug interactions and ensure the safety and effectiveness of medications.
Date :
  1. Date Completed 2022-04-20
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

35086735

DOI: Digital Object Identifier

10.1016/j.clinthera.2021.11.009

Related Literature

Article Analysis
・Effects of plecanatide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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