Comparative hypotensive effects of acebutolol and hydrochlorothiazide in patients with mild to moderate essential hypertension: a double-blind multicenter evaluation.

Author: SinghB N, ThodenW R, WahlJ

Paper Details 
Original Abstract of the Article :
A double-blind multicenter study compared oral acebutolol (n = 182) with hydrochlorothiazide (n = 178) in the treatment of mild to moderate essential hypertension (diastolic blood pressure 95 to 114 mm Hg). Both agents produced significant and comparable reductions in systolic, diastolic, and mean a...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/0002-8703(86)90153-5

データ提供:米国国立医学図書館(NLM)

Acebutolol vs Hydrochlorothiazide: A Head-to-Head Comparison for Hypertension

The world of [hypertension] is a vast and complex landscape, where finding the right medication is crucial for managing this prevalent condition. This study compares the effectiveness and tolerability of two commonly used [antihypertensive drugs]: [acebutolol] and [hydrochlorothiazide]. The researchers conducted a [double-blind multicenter study] to evaluate the impact of these drugs on [blood pressure] and [heart rate] in patients with [mild to moderate essential hypertension], much like a desert explorer carefully comparing different routes to find the most suitable path.

Acebutolol and Hydrochlorothiazide: Comparable Effectiveness in Hypertension

The study found that both [acebutolol] and [hydrochlorothiazide] produced significant and comparable reductions in [blood pressure], suggesting that both drugs are effective in managing [hypertension]. However, [acebutolol] was associated with fewer [adverse events], particularly [arrhythmia, anorexia, and flatulence]. These findings suggest that [acebutolol] might be a more tolerable option for some patients, much like a desert traveler might choose a path with fewer obstacles and a more comfortable terrain.

Navigating Hypertension Treatment: Considerations for Acebutolol and Hydrochlorothiazide

This study provides valuable information for physicians and patients who are managing [hypertension]. While both [acebutolol] and [hydrochlorothiazide] are effective in reducing [blood pressure], [acebutolol] may offer a more favorable [side effect profile] for some individuals. The choice of medication should be made on a case-by-case basis, considering the patient's individual [medical history], [risk factors], and [preferences]. It's like navigating a desert landscape, where the optimal route depends on the individual traveler's strengths, weaknesses, and goals.

Dr. Camel's Conclusion

This study highlights the importance of carefully considering [side effect profiles] when choosing [antihypertensive medications]. While both [acebutolol] and [hydrochlorothiazide] are effective in managing [hypertension], [acebutolol] may offer a more tolerable option for some patients. It's a reminder that the journey of managing [hypertension] is not a one-size-fits-all approach, and finding the right medication for each individual is key to success.

Date :
  1. Date Completed 1986-03-10
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

3511650

DOI: Digital Object Identifier

10.1016/0002-8703(86)90153-5

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.