Side Effects of acebutolol: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Major Research Findings

Acebutolol is a beta-blocker used to treat heart conditions such as hypertension, angina, atrial fibrillation, and premature ventricular contractions. These studies have shown that acebutolol is generally a safe and effective drug, but some side effects have been reported. 15 , 17 , 18 , 19 , 23 , 22 , 21 , 4 , 2 , 12 , 7 , 8 , 13 , 9 , 6 , 3

Reasons for Side Effects

Side effects of acebutolol occur because the drug works on the beta receptors in the heart. Beta receptors are responsible for regulating the heart's contractility, heart rate, and blood pressure. Acebutolol binds to these receptors, inhibiting these functions. Therefore, acebutolol can weaken the heart's contractility, slow the heart rate, or lower blood pressure. In addition, acebutolol can also affect the function of other organs because it acts on beta receptors in these organs.

Common Side Effects

Fatigue

One common side effect of acebutolol is fatigue. 5

Dizziness

Dizziness is another common side effect of acebutolol. 10 , 17

Headache

Headache has been reported as a side effect of acebutolol. 16

Difficulty Breathing

Acebutolol can cause bronchospasm, which can lead to difficulty breathing. 17

Indigestion

Indigestion has also been reported as a side effect of acebutolol. 18

Decreased Heart Rate

Acebutolol can lower heart rate, so decreased heart rate can occur. 12 , 17

Low Blood Pressure

Acebutolol can lower blood pressure, so low blood pressure can occur. 17

Insomnia

Insomnia has been reported as a side effect of acebutolol. 17

Depression

Depression has been reported as a side effect of acebutolol. 17

Countermeasures for Side Effects

Fatigue

Countermeasures for fatigue include getting enough sleep and exercising lightly.

Dizziness

If you feel dizzy, be careful to stand up slowly when you get up.

Headache

If you have a headache, take an over-the-counter pain reliever.

Difficulty Breathing

If you have difficulty breathing, talk to your doctor. Bronchodilators may be prescribed if necessary.

Indigestion

If you have indigestion, try making dietary changes or taking digestive enzymes.

Decreased Heart Rate

If your heart rate is too low, talk to your doctor.

Low Blood Pressure

If you have low blood pressure, talk to your doctor.

Insomnia

If you have insomnia, take sleeping pills or make adjustments to help you relax before bed.

Depression

If you have persistent symptoms of depression, talk to your doctor. Antidepressants may be prescribed if necessary.

Comparison Among Studies

Commonalities Among Studies

All these studies have shown that acebutolol is generally a safe and effective drug. 15 , 17 , 18 , 19 , 23 , 22 , 21 , 4 , 2 , 12 , 7 , 8 , 13 , 9 , 6 , 3

Differences Among Studies

These studies have found varying frequencies and types of side effects related to acebutolol. This could be due to differences in the study populations and study designs.

Points to Note Regarding Application to Real Life

When taking acebutolol, be sure to follow your doctor's instructions carefully and consult your doctor immediately if you experience any side effects. In particular, be careful when driving or operating machinery as side effects such as dizziness may occur. Also, acebutolol should not be taken by pregnant or breastfeeding women. 4

Limitations of Current Research

Research on the side effects of acebutolol is still insufficient. In particular, research on long-term side effects is lacking.

Future Research Directions

Further research is needed to clarify the long-term side effects of acebutolol and individual differences in side effects. Research is also needed on new methods to mitigate side effects of acebutolol.

Conclusion

Acebutolol is a beta-blocker used to treat heart conditions such as hypertension, angina, atrial fibrillation, and premature ventricular contractions. Acebutolol is generally a safe and effective drug, but side effects such as fatigue, dizziness, and headache may occur. Consult your doctor if you have concerns about side effects. Acebutolol should not be taken by pregnant or breastfeeding women. 4

Keywords
Benefit Keywords
Reduced anxiety
Reduced arousal
1
Hemangioma resolution
2
Circulatory benefits
3
Subglottic hemangioma treatment
4
Beta-blockers
Neurocardiogenic syncope treatment
5
Lupus diagnosis
6
Blood pressure reduction
Cardiovascular event prevention
Quality of life improvement
7
Blood pressure reduction
Hypertension treatment
8
Blood pressure reduction
9
Blood pressure management
Quality of life improvement
10
Blood pressure normalization
Effective hypertension therapy
11
blood pressure control
safe
12
Blood pressure reduction
Effective hypertension treatment
13
Reduced arrhythmias
Reduced blood pressure
Reduced sudden death
14
Improved mild hypertension
15
Blood pressure reduction
Effective antihypertensive
16
Effective for angina
Effective for arrhythmias
Effective for hypertension
17
Hypertension treatment
18
Hypertension treatment
Well tolerated
19
Diabetes safety
Hypertension treatment
20
Angina relief
21
Improved heart rhythm
Reduced premature ventricular contractions
22
Improved hypertension
Reduced blood pressure
23
Risk Keywords
Bradycardia
Hypoglycemia
Hypotension
Wheezing
2
Ineffective for AF
3
Side effects
5
Adverse events
Electrocardiographic abnormalities
7
Side effects
8
Transient side effects
11
Dropouts
Side effects
13
Decreased ventricular function
Increased airways resistance
Increased plasma lipids
Increased problems in patients with diabetes requiring insulin treatment
Increased problems in patients with peripheral vascular disease
14
Side effects
15
Headache
16
Cautious use in bronchospastic disease
17
ANA positivity
Anorexia
Arrhythmia
BUN abnormalities
Chloride abnormalities
Flatulence
Glucose abnormalities
Potassium abnormalities
Uric acid abnormalities
18
None mentioned
19
Side effects
21
Mild side effects
22
Heart rate reduction
23
Literature analysis of 23 papers
Positive Content
22
Neutral Content
1
Negative Content
0
Article Type
13
0
0
4
23
1.

The psychological side effects of acebutolol and atenolol.

Author: LewisM J, JonesD M, DartA M, HendersonA H

Reduced anxiety
Reduced arousal

Atenolol significantly reduced arousal in patients with essential hypertension, while acebutolol effectively decreased anxiety but only during the first two weeks of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Comparative efficacy and usefulness of acebutolol and diltiazem for the prevention of atrial fibrillation during perioperative time in patients undergoing pulmonary resection.

Author: CiszewskiPawel, TyczkaJoanna, NadolskiJacek, RoszakMagdalena, DyszkiewiczWojciech

Circulatory benefits
Ineffective for AF

Acebutolol and diltiazem were not effective in preventing or treating postthoracic surgery atrial fibrillation (AF). Acebutolol, however, had a beneficial effect on the circulatory system, reducing the occurrence of tachycardia and supraventricular ectopy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The clinical utility of antihistone antibodies. Autoantibodies reactive with chromatin in systemic lupus erythematosus and drug-induced lupus.

Author: BurlingameR W

Lupus diagnosis

This article discusses the diagnostic utility of autoantibodies reactive with histones and chromatin in systemic lupus erythematosus (SLE). The presence of antichromatin antibodies is helpful in diagnosing SLE and drug-induced lupus, while antibodies to denatured histones have limited diagnostic value.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group.

Author: NeatonJ D, GrimmR H, PrineasR J, StamlerJ, GranditsG A, ElmerP J, CutlerJ A, FlackJ M, SchoenbergerJ A, McDonaldR

Blood pressure reduction
Cardiovascular event prevention
Quality of life improvement
Adverse events
Electrocardiographic abnormalities

This randomized, double-blind, placebo-controlled clinical trial found that drug treatment in combination with nutritional-hygienic intervention was more effective in preventing cardiovascular and other clinical events than was nutritional-hygienic treatment alone. The study involved 837 hypertensive men and women, aged 45 to 69 years, with diastolic blood pressure less than 100 mm Hg.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

Overview of clinical safety and efficacy of tertatolol.

Author: VivetP

Blood pressure reduction
Hypertension treatment
Side effects

Tertalolol, a beta-blocker, effectively lowers blood pressure and improves heart rate at submaximal exercise. It is safe and effective, with only 6.6% of patients experiencing side effects after 1 year of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

The treatment of mild hypertension study. A randomized, placebo-controlled trial of a nutritional-hygienic regimen along with various drug monotherapies. The Treatment of Mild Hypertension Research Group.

Author:

Blood pressure reduction

Nutritional-hygienic therapy alone was effective in lowering blood pressure in individuals with mild hypertension, while adding one of five different classes of antihypertensive agents resulted in significantly greater reductions with minimal short-term side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS).

Author: MascioliS R, GrimmR H, NeatonJ D, StamlerJ, PrineasR J, CutlerJ A, ElmerP J, McDonaldR, SchnaperH, SchoenbergerJ

Blood pressure management
Quality of life improvement

The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial comparing the effects of nonpharmacologic therapy alone with those of five active drug regimens, including acebutolol, amlodipine, chlorthalidone, doxazosin, and enalapril, combined with nonpharmacologic therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

[Therapy of moderate hypertension with the calcium antagonist nitrendipine in combination with beta receptor blocker or diuretic].

Author: OverlackA, MüllerH M, KollochR, StumpeK O

Blood pressure normalization
Effective hypertension therapy
Transient side effects

Nitrendipine, a calcium channel blocker, was found to be effective in lowering blood pressure in patients with moderate essential hypertension. Adding acebutolol or hydrochlorothiazide to nitrendipine further lowered blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

Effect of bisoprolol and acebutolol on resting blood pressure and on exercise blood pressure profile in hypertensive patients: a comparative, single-blind study.

Author: BouvierJ M, RabotD, HerreroG

blood pressure control
safe

This study compared the efficacy and safety of bisoprolol (B) and acebutolol (A) on blood pressure at rest and during exercise in hypertensives. Both drugs significantly reduced blood pressure at rest and during exercise, with bisoprolol exerting a hypotensive effect at least equivalent to that of acebutolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Efficacy and tolerance of nifedipine retard vs acebutolol in patients with essential hypertension treated for 26 weeks.

Author: ChamiecT, ZaleskaT, KłośJ, PietrzykowskaH, BednarzB, CeremuzyńskiL

Blood pressure reduction
Effective hypertension treatment
Dropouts
Side effects

Nifedipine Retard and Acebutolol, antihypertensive drugs, were compared in patients with essential hypertension. Both drugs effectively reduced blood pressure, but Nifedipine Retard caused fewer side effects and less drop-outs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Background and design of the new U.S. trial on diet and drug treatment of "mild" hypertension (TOMHS).

Author: StamlerJ, PrineasR J, NeatonJ D, GrimmR H, McDonaldR H, SchnaperH W, SchoenbergerJ A, ElmerP J, CutlerJ A

Improved mild hypertension
Side effects

A multicenter trial is comparing the combined effects of diet treatment and 5 active drug regimens with diet treatment alone in middle-aged adults with mild hypertension. The trial is designed to evaluate the long-term management of mild hypertension and assess the effects on morbidity and mortality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks.

Author: M'Buyamba-KabanguJ R, FagardR, LijnenP, StaessenJ, LissensW, DituM, LepiraB, TshianiK A, AmeryA

Blood pressure reduction
Effective antihypertensive
Headache

Nitrendipine and acebutolol were effective in controlling hypertension in Black patients. Nitrendipine was slightly more effective than acebutolol in reducing blood pressure, but both medications were safe and well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.

Author: SinghB N, ThodenW R, WahlJ

Effective for angina
Effective for arrhythmias
Effective for hypertension
Cautious use in bronchospastic disease

Acebutolol, a cardioselective beta-adrenergic-blocking agent, effectively controlled mild to moderate essential hypertension. It was as effective as other beta-blocking agents, but caused less reduction in heart rate and fewer neurologic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Comparative hypotensive effects of acebutolol and hydrochlorothiazide in patients with mild to moderate essential hypertension: a double-blind multicenter evaluation.

Author: WahlJ, SinghB N, ThodenW R

Hypertension treatment
ANA positivity
Anorexia
Arrhythmia
BUN abnormalities
Chloride abnormalities
Flatulence
Glucose abnormalities
Potassium abnormalities
Uric acid abnormalities

Acebutolol and hydrochlorothiazide were compared in 360 patients with mild to moderate essential hypertension. Both drugs produced significant and comparable reductions in blood pressure. Acebutolol was associated with fewer arrhythmia, anorexia, and flatulence, while hydrochlorothiazide was associated with more biochemical abnormalities.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

19.

A comparative study of two beta-blocker-diuretic combinations in the treatment of hypertension.

Author: LubisH R, SilalahiM, Yushar

Hypertension treatment
Well tolerated
None mentioned

Both propranolol/hydrochlorothiazide and acebutolol/hydrochlorothiazide combinations were effective in reducing blood pressure in patients with essential hypertension. The acebutolol combination produced a significantly greater reduction in diastolic blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Acebutolol in the treatment of diabetic patients with hypertension.

Author: FraserD M, NimmoG R, PolonieckiJ D

Diabetes safety
Hypertension treatment

Acebutolol was more effective than placebo in lowering blood pressure in 20 diabetic patients with mild to moderate hypertension. The study showed no deterioration in diabetic control or significant side effects for acebutolol compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Double blind cross-over clinical trial of acebutolol and propranolol in angina pectoris.

Author: PandhiP, SethiV, SharmaB K, WahiP L, SharmaP L

Angina relief
Side effects

Acebutolol (100-400 mg) and propranolol (40-160 mg) three times a day effectively reduced anginal attacks, nitroglycerine tablet consumption, and increased exercise tolerance in 24 patients. Both drugs had mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Acebutolol for premature ventricular contractions: short- and long-term effects.

Author: de SoyzaN

Improved heart rhythm
Reduced premature ventricular contractions
Mild side effects

Oral acebutolol therapy was safe and effective in suppressing premature ventricular contractions in patients with organic heart disease.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Once-daily acebutolol and atenolol in essential hypertension: double-blind crossover comparison.

Author: TurnerA S, BrocklehurstJ C, NapierR N

Improved hypertension
Reduced blood pressure
Heart rate reduction

Acebutolol and atenolol were equally effective in treating mild to moderate essential hypertension. Acebutolol was better tolerated and had a smaller effect on heart rate than atenolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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