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Tamoxifen side effects: pharmacogenetic and clinical approach in Mexican mestizos.

Author: Moo-PucRosa Esther, Rangel-MéndezJorge-Aarón, Rubi-CastellanosRodrigo, Sánchez-CruzJuan-Francisco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated <i>CYP2D6</i> genotype and clinical variables as potential predictors of tamoxifen side effects (TSE) in Mexican Mestizo patients.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Tamoxifen metabolism is translated into four genetic phenotypes (GP): genetic poor metabolizer (gPM); genetic intermediate metabolizer (gIM); genetic normal metabolizer (gNM); and genetic ultra-rapid metabolizer (gUM). Although <i>CYP2D6</i> is involved in...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798170/

データ提供：米国国立医学図書館（NLM）

Tamoxifen Side Effects: A Pharmacogenetic Perspective in Mexican Mestizos

This research delves into the fascinating world of pharmacogenetics, exploring the influence of genetic variations on drug response and side effects. Researchers investigated the association between specific genetic variations in the CYP2D6 gene and the occurrence of tamoxifen side effects (TSE) in Mexican Mestizo patients receiving tamoxifen, a medication commonly used to treat breast cancer.

CYP2D6 Gene Variation and Tamoxifen Side Effects

The study explored the relationship between CYP2D6 genetic phenotypes and the likelihood of experiencing TSE. Although CYP2D6 plays a significant role in tamoxifen metabolism, the study found limited evidence to support a direct association between specific genetic variations and the occurrence of TSE. These findings suggest that other factors, such as individual patient characteristics, might play a more prominent role in TSE development.

Individualized Treatment: A Key to Success

This study underscores the importance of personalized medicine, considering individual factors beyond genetics when prescribing medications. It suggests that a comprehensive approach to patient care, including genetic testing, clinical evaluation, and careful monitoring, is essential for optimizing treatment outcomes and minimizing side effects. Just as a desert traveler adapts their journey based on individual circumstances, healthcare professionals must personalize their treatment plans to ensure the best possible care for their patients.

Dr.Camel's Conclusion

This research highlights the complex interplay between genetics and drug response. It emphasizes the need for a personalized approach to medication management, considering individual factors beyond genetics. It's a reminder that the journey towards optimal treatment involves careful assessment, tailored strategies, and continuous monitoring to ensure the best possible outcomes for patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-05-01
Further Info :

Pubmed ID

35116730

DOI: Digital Object Identifier

PMC8798170

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・Side Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

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