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Guanfacine as monotherapy for systemic hypertension.

Author: BlackshearJ L, FillingimJ M, StraussA, StraussM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Guanfacine monotherapy was studied in three clinical trials of patients with mild essential hypertension. Guanfacine was found to be effective in lowering diastolic blood pressure without affecting plasma volume, plasma aldosterone, or serum lipids. No significant side effects were reported.
Paper Details　
Original Abstract of the Article :
Three clinical studies examined the effects of guanfacine as monotherapy. Study 1 was a double-blind, randomized, parallel trial with a placebo control with 26 patients with mild essential hypertension treated with 1-mg guanfacine or matching placebo daily at bedtime for 8 weeks. Pretreatment and po...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9149(86)90724-1

データ提供：米国国立医学図書館（NLM）

Guanfacine Monotherapy for Systemic Hypertension: A Promising Treatment Option

This research dives into the realm of hypertension treatment, investigating the effectiveness of guanfacine as a monotherapy for mild essential hypertension. Through a series of double-blind, randomized, placebo-controlled trials, the authors meticulously analyze the effects of guanfacine on blood pressure and other physiological parameters. Their findings suggest that guanfacine monotherapy is a well-tolerated and effective initial treatment for mild essential hypertension, without any significant impact on plasma volume or plasma aldosterone levels.

A Gentle Approach: Guanfacine Shows Promise for Hypertension

The research suggests that guanfacine monotherapy is a safe and effective treatment option for mild essential hypertension. The studies demonstrate that guanfacine effectively lowers both diastolic and mean blood pressure without causing significant side effects or impacting other physiological parameters. Think of guanfacine like a gentle breeze in the desert – a refreshing and soothing approach to managing blood pressure.

Navigating the Desert of Hypertension: Finding Effective Treatment

As a researcher, I am always eager to uncover new and effective treatment options for common health conditions. This research highlights the potential benefits of guanfacine monotherapy as a safe and effective treatment for mild essential hypertension. The findings emphasize the importance of individualized treatment approaches tailored to the specific needs of patients, highlighting the need for a personalized approach to healthcare.

Dr.Camel's Conclusion

This research explores the effectiveness of guanfacine as a monotherapy for mild essential hypertension. The findings suggest that guanfacine is a well-tolerated and effective treatment option, offering a promising alternative for managing blood pressure. It's like finding a hidden oasis in the desert – a refreshing and effective solution for individuals struggling with hypertension.
Date :
  1. Date Completed 1986-04-23
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

3513531

DOI: Digital Object Identifier

10.1016/0002-9149(86)90724-1

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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