Paper Details

  1. Home
  2. Paper Details

Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus.

Author: BellP M, FirthR G, RizzaR A

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Sulfonylureas and exogenous insulin were compared in eight patients with non-insulin-dependent diabetes mellitus. Both treatments resulted in similar improvements in glycemic control, lowering of glucose-production rates, and increasing glucose utilization. Neither agent altered erythrocyte insulin binding.
Paper Details　
Original Abstract of the Article :
To determine whether sulfonylureas and exogenous insulin have different effects on insulin action, we studied eight patients with non-insulin-dependent diabetes mellitus before and after three months of treatment with tolazamide and exogenous semisynthetic human insulin, using a randomized crossover...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1056/NEJM198605153142003

データ提供：米国国立医学図書館（NLM）

Tolazamide and Exogenous Insulin: A Comparative Study in Non-Insulin-Dependent Diabetes Mellitus

Non-insulin-dependent diabetes mellitus (NIDDM) is a chronic condition that requires careful management. This study investigates the effects of tolazamide, a sulfonylurea drug, and exogenous insulin on insulin action in patients with NIDDM. The researchers aim to determine whether these two treatment options have different effects on insulin sensitivity and glucose metabolism.

Tolazamide and Exogenous Insulin Show Similar Effects on Insulin Action

The study found that both tolazamide and exogenous insulin led to similar improvements in glycemic control, lowering glucose production rates and increasing glucose utilization. The study concluded that both treatment options effectively ameliorate insulin resistance in NIDDM patients.

Navigating the Desert of Diabetes Management: A Choice of Paths

This research highlights the need for a personalized approach to diabetes management. It suggests that the choice between tolazamide and exogenous insulin should be based on factors other than their ability to improve insulin sensitivity. It's like navigating a vast desert, where different paths can lead to the same destination, and the choice depends on individual preferences and circumstances.

Dr.Camel's Conclusion

This study underscores the complexity of diabetes management and highlights the importance of individualized treatment plans. It's a reminder that there's no one-size-fits-all solution to diabetes, and finding the right path requires close collaboration between patients and healthcare providers.
Date :
  1. Date Completed 1986-06-06
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

3517644

DOI: Digital Object Identifier

10.1056/NEJM198605153142003

Related Literature

Article Analysis
・Effects of tolazamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.