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Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells.
Author: Aldaba-MuruatoLiseth Rubi, Macías-PérezJosé Roberto, Martínez-HernándezSandra Luz, Medina-PizañoMariana Yazmin, Medina-RosalesMarina Nayeli, Muñoz-OrtegaMartin Humberto, Sánchez-AlemánEsperanza, Ventura-JuárezJavier
Original Abstract of the Article :
Doxazosin and carvedilol have been evaluated as an alternative treatment against chronic liver lesions and for their possible role during the regeneration of damage caused by liver fibrosis in a hamster model. However, these drugs have been reported to induce morphological changes in hepatocytes, af...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856820/
データ提供：米国国立医学図書館（NLM）
Curcumin: A Potential Protector Against Doxazosin and Carvedilol-Induced Oxidative Stress
Doxazosin and carvedilol, medications often used to treat chronic liver lesions and liver fibrosis, have shown potential benefits. However, these drugs have also been associated with morphological changes in hepatocytes, raising concerns about their impact on liver health. This research investigates the protective effects of curcumin, a natural compound found in turmeric, against the potential side effects of doxazosin and carvedilol. The authors used HepG2 cells, a human liver cell line, to study the effects of these drugs, both individually and in combination with curcumin. Their findings suggest that curcumin may mitigate the negative impacts of doxazosin and carvedilol on hepatocyte viability and morphology, potentially enhancing the safety profile of these medications.
Curcumin: A Potential Ally in Liver Health
This research suggests that curcumin, a natural compound found in turmeric, may offer a protective shield against the potential side effects of doxazosin and carvedilol. It's like finding a hidden oasis in the vast desert of liver health research, offering a potential solution to the challenges associated with these medications. This research opens new doors for exploring the therapeutic potential of curcumin in conjunction with these medications, potentially improving their safety profile and efficacy.
The Importance of Natural Compounds in Healthcare
This research highlights the potential of natural compounds like curcumin in improving human health. It's a reminder that the vast desert of nature holds a wealth of medicinal treasures, waiting to be discovered. This research encourages us to explore the therapeutic potential of natural compounds, as they may offer valuable solutions to health challenges.
Dr.Camel's Conclusion
The findings suggest that curcumin may offer a protective shield against the potential side effects of doxazosin and carvedilol. It's like finding a hidden oasis in the vast desert of liver health research, offering a potential solution to the challenges associated with these medications. This research opens new doors for exploring the therapeutic potential of curcumin in conjunction with these medications, potentially improving their safety profile and efficacy.
Date :
- Date Completed 2022-03-17
- Date Revised 2022-03-17
Further Info :
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