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Molecular Basis for the Interaction of Catalase with d-Penicillamine: Rationalization of Some of Its Deleterious Effects.

Author: GalardonErwan, PadovaniDominique

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the molecular basis of d-penicillamine's side effects, focusing on its interaction with catalase. d-Penicillamine was found to inactivate catalase, potentially disrupting H2O2 redox homeostasis, which may contribute to the observed side effects.
Paper Details　
Original Abstract of the Article :
d-Penicillamine (d-Pen) is a sulfur compound used in the management of rheumatoid arthritis, Wilson's disease (WD), and alcohol dependence. Many side effects are associated with its use, particularly after long-term treatment. However, the molecular basis for such side effects is poorly understood. ...See full text at original site
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引用元：
https://doi.org/10.1021/acs.chemrestox.1c00313

データ提供：米国国立医学図書館（NLM）

d-Penicillamine and Catalase: A Tale of Unforeseen Interactions

Greetings from Dr. Camel, your guide through the intricate world of biochemical reactions. This study explores the interaction between d-penicillamine, a drug used to treat various conditions, and catalase, a crucial enzyme involved in protecting cells from oxidative stress. It's like observing a chemical sandstorm, where the unexpected interaction of two elements can have unforeseen consequences.

Unveiling the Unforeseen: The Interaction of d-Penicillamine and Catalase

The researchers investigated how d-penicillamine interacts with catalase, finding that the drug can temporarily inactivate this important enzyme. It's like observing a sandstorm temporarily blocking a vital oasis, hindering the flow of essential resources. This inactivation could contribute to the various side effects associated with d-penicillamine, highlighting the importance of understanding the complex interactions between drugs and biological systems.

A Desert of Side Effects: Navigating the Risks of d-Penicillamine

This study underscores the importance of being mindful of the potential side effects of medications, even those commonly prescribed. It's like recognizing the dangers of a sandstorm, knowing that it can disrupt the delicate balance of the desert environment. If you are taking d-penicillamine, it's crucial to discuss any concerns with your doctor and to be aware of potential side effects. This careful monitoring is essential for ensuring your safety and well-being.

Dr.Camel's Conclusion

This study provides a fascinating glimpse into the complex interplay of molecules within our bodies. It reminds us that even seemingly innocuous interactions can have significant consequences. As I continue my research journey, I'm eager to learn more about these intricate relationships, seeking to understand the delicate balance of the chemical desert within us.

Date :
  1. Date Completed 2022-04-25
  2. Date Revised 2022-04-25
Further Info :

Pubmed ID

35191669

DOI: Digital Object Identifier

10.1021/acs.chemrestox.1c00313

SNS
PICO Info
in preparation
Languages

English

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