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Local control and survival in early breast cancer: the Milan trial.

Author: LuiniA, VeronesiU, ZucaliR

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effectiveness of Halsted mastectomy (removal of the entire breast) to a less extensive procedure (quadrantectomy) with lymph node removal and radiation for 701 patients with small (less than 2 cm) breast cancer without lymph node involvement. After 8 years, there was no significant difference in disease-free or overall survival between the two groups, with both groups achieving high survival rates (77-80% for disease-free survival and 83-85% for overall survival). The study concludes that smaller breast cancers can be safely and effectively treated with a less invasive procedure, and that extensive surgery is not necessary.
Paper Details　
Original Abstract of the Article :
From 1973 to 1980, 701 patients with breast cancer measuring less than 2 cm in pathological diameter and with no palpable axillary lymph nodes were randomized to Halsted mastectomy (349) or to "quadrantectomy" with axillary dissection and radiotherapy to the ipsilateral breast tissue (QUART) (352). ...See full text at original site
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引用元：
https://doi.org/10.1016/0360-3016(86)90027-1

データ提供：米国国立医学図書館（NLM）

Local Control and Survival in Early Breast Cancer

This study examines the effectiveness of different treatment approaches for early breast cancer, specifically comparing Halsted mastectomy (removal of the entire breast) with a more conservative approach known as 'quadrantectomy' (removal of a quadrant of the breast) followed by axillary dissection and radiation therapy. The researchers conducted a randomized controlled trial involving 701 patients with early breast cancer, assessing the long-term outcomes of both treatment approaches. The findings suggest that both approaches are equally effective in terms of survival and disease-free survival, providing evidence to support a less invasive treatment option for early breast cancer.

Halsted Mastectomy vs. Quadrantectomy

The study found no significant differences in disease-free survival or overall survival between patients who received Halsted mastectomy and those who received quadrantectomy with axillary dissection and radiation therapy. These results demonstrate that quadrantectomy can be a safe and effective alternative to mastectomy for women with early breast cancer.

Early Breast Cancer Treatment Options

The study provides valuable evidence supporting the use of conservative surgery for early breast cancer, offering a less invasive and potentially less traumatic treatment option. It emphasizes the importance of individualized treatment plans and careful consideration of all available treatment options based on the individual patient's needs and preferences.

Dr.Camel's Conclusion

Imagine a camel caravan facing a fierce sandstorm. Halsted mastectomy is like a formidable shield that can protect the caravan from the storm's full force, but it can also leave the caravan vulnerable and exposed. Quadrantectomy is like a lighter shield that provides protection while allowing the caravan to move more freely. This research suggests that both approaches can effectively navigate the storm, allowing the caravan to continue its journey with strength and resilience.
Date :
  1. Date Completed 1986-06-27
  2. Date Revised 2019-07-08
Further Info :

Pubmed ID

3519549

DOI: Digital Object Identifier

10.1016/0360-3016(86)90027-1

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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