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Case Report: Genetic Analysis of PEG-Asparaginase Induced Severe Hypertriglyceridemia in an Adult With Acute Lymphoblastic Leukaemia.

Author: AlibertiEmilio, AnnunziataMario, BrescianiAlessandro, FortunatoGiuliana, GiacobbeCarola, IannuzziArcangelo, IannuzzoGabriella, PalmaDaniela

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

A 28-year-old male developed severe hypertriglyceridemia after treatment with PEG-asparaginase for acute lymphoblastic leukaemia. Genetic analysis revealed a rare heterozygous missense variant c.11G > A-p.(Arg4Gln) in the APOC3 gene and its association with four common single nucleotide polymorphisms (SNPs) related to increased plasma triglyceride levels.
Paper Details　
Original Abstract of the Article :
PEG-Asparaginase (also known as Pegaspargase), along with glucocorticoids (predominantly prednisolone or dexamethasone) and other chemotherapeutic agents (such as cyclophosphamide, idarubicin, vincristine, cytarabine, methotrexate and 6-mercaptopurine) is the current standard treatment for acute lym...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882989/

データ提供：米国国立医学図書館（NLM）

PEG-Asparaginase: A Case of Drug-Induced Hypertriglyceridemia

Acute lymphoblastic leukaemia (ALL) is a serious cancer, and treatments like PEG-asparaginase are vital for fighting it. However, this case report highlights a potential side effect of PEG-asparaginase - severe hypertriglyceridemia, a condition characterized by high levels of triglycerides in the blood.

Genetic Susceptibility

This case report provides a valuable insight into the potential role of genetic factors in drug-induced hypertriglyceridemia. The patient's genetic analysis revealed a rare variant in the APOC3 gene, suggesting a possible predisposition to this side effect. Think of it like a genetic map, revealing certain individuals might be more vulnerable to specific drug reactions.

Personalized Treatment Strategies

This case report emphasizes the importance of personalized treatment strategies, taking into account individual genetic factors. It's a reminder that one size does not fit all when it comes to drug therapy.

Dr. Camel's Conclusion

This case report serves as a reminder that even seemingly safe medications can have unexpected side effects, and that genetic factors play a crucial role in determining individual responses to drugs. It's essential to be aware of these possibilities and to tailor treatment strategies to each patient's unique genetic profile.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-04
Further Info :

Pubmed ID

35237305

DOI: Digital Object Identifier

PMC8882989

SNS
PICO Info
in preparation
Languages

English

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