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Controlled studies of the efficacy and safety of combined probucol-colestipol therapy.

Author: ChernoffS B, DujovneC A, KrehbielP

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Combined probucol-colestipol therapy was more effective in lowering LDL cholesterol levels than either drug alone in hypercholesterolemic patients. The combination therapy was also well tolerated and significantly reduced the gastrointestinal side effects of either drug used alone.
Paper Details　
Original Abstract of the Article :
A comprehensive clinical evaluation of the effects of combined probucol-colestipol therapy was undertaken in 71 hypercholesterolemic patients. In the first 18-month double-blind, double-placebo, crossover study, the effects of 1 g/day of probucol and 20 g/day of colestipol were compared with the dru...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9149(86)90435-2

データ提供：米国国立医学図書館（NLM）

Combating Cholesterol: A Collaborative Approach

Greetings, my fellow adventurers in the desert of medical research! I'm Dr. Camel, and I'm always eager to explore new paths towards better health. This study focuses on the combined use of probucol and colestipol, two drugs used to lower cholesterol levels. It's like combining the strength of two camels to carry a heavy load across a challenging terrain. The study found that this combination was more effective than using either drug alone in reducing cholesterol levels. It's like finding a shortcut through the desert, leading to a faster and more efficient journey.

A Winning Formula for Cholesterol Control

This study provides compelling evidence for the efficacy of combined probucol-colestipol therapy in lowering cholesterol. The results are encouraging, suggesting that a synergistic effect can be achieved by combining different approaches. It's like discovering a hidden spring that provides a more abundant and nourishing source of water. The researchers also found that the combination reduced the gastrointestinal side effects associated with the individual drugs, making it a more tolerable option for many patients.

Navigating the Desert of High Cholesterol

This research highlights the importance of finding the right approach to manage high cholesterol. It emphasizes the potential benefits of combining different treatments to achieve optimal results. It's like carefully selecting the best camels for your caravan, ensuring a safe and successful journey through the desert of high cholesterol. Always consult with a healthcare professional to determine the best treatment plan for your individual needs.

Dr.Camel's Conclusion

Combined probucol-colestipol therapy offers a promising approach to lowering cholesterol, providing a more effective and well-tolerated option for patients. It's like finding a new oasis in the desert, providing relief and a chance for a healthier future.
Date :
  1. Date Completed 1986-07-31
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

3524176

DOI: Digital Object Identifier

10.1016/0002-9149(86)90435-2

Related Literature

Article Analysis
・Side Effects of colestipol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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