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Adjunctive antidepressants for the acute treatment of bipolar depression: A systematic review and meta-analysis.

Author: HuYuliang, KungSimon, LiChunbo, WangChris, WangHongyan, ZhangHuijuan

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Adjunctive antidepressants did not clinically improve the response rate or depressive symptoms in patients with acute bipolar depression. They were well-tolerated and did not increase the risk of short-term mood switch.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The depressive phase of bipolar disorder causes significant functional impairment and disease burden. The efficacy and safety of antidepressants in the treatment of bipolar depression has long been a subject of debate. AIMS: To synthesize evidence of the effectiveness, risk of mood swit...See full text at original site
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引用元：
https://doi.org/10.1016/j.psychres.2022.114468

データ提供：米国国立医学図書館（NLM）

Adjunctive Antidepressants for Bipolar Depression

The management of [bipolar disorder] presents a significant challenge, particularly during the [depressive phase] of the illness. This study examines the efficacy and safety of [adjunctive antidepressants] in the treatment of acute bipolar depression. The researchers conducted a [systematic review and meta-analysis] of randomized controlled trials to assess the effectiveness of adding antidepressants to mood stabilizers or antipsychotics in treating bipolar depression.

Antidepressants and Bipolar Depression: Limited Evidence

The study found that [adjunctive antidepressants] showed no significant effect on [improving response rate] or [depressive symptoms] in acute bipolar depression. While there was a small but statistically significant improvement in response rate when antidepressants were combined with antipsychotics, this finding was limited by the predominance of olanzapine as the antipsychotic medication. Despite the lack of significant clinical improvement, adjunctive antidepressants were well tolerated and did not increase the risk of [mood switching].

Antidepressant Use in Bipolar Disorder: A Cautious Approach

This study emphasizes the need for [caution] in using adjunctive antidepressants for acute bipolar depression. The lack of evidence for clinical improvement underscores the importance of [carefully considering the potential risks and benefits] of this treatment strategy. The authors suggest that [further research] is needed to understand the role of adjunctive antidepressants in the management of bipolar depression.

Dr.Camel's Conclusion

Bipolar disorder can be a challenging condition to manage, requiring a multifaceted approach to treatment. This study highlights the need for a cautious approach to using adjunctive antidepressants for acute bipolar depression, given the limited evidence for clinical improvement. Just like a camel carefully navigating a desert path, clinicians must weigh the potential benefits and risks of different treatment strategies to ensure the best possible outcomes for patients with bipolar disorder.

Date :
  1. Date Completed 2022-04-19
  2. Date Revised 2022-05-09
Further Info :

Pubmed ID

35248807

DOI: Digital Object Identifier

10.1016/j.psychres.2022.114468

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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