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Acute Effects of Liothyronine Administration on Cardiovascular System and Energy Metabolism in Healthy Volunteers.

Author: AbbateAntonio, CarboneSalvatore, CeliFrancesco S, ChenShanshan, Van TassellBenjamin, Vecchie'Alessandra, WohlfordGeorge F, YavuzSahzene

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study found that a high dose of liothyronine did not have any measurable rapid effects on the cardiovascular system. This supports the rationale for conducting long-term studies to assess the safety and effectiveness of liothyronine in patients with hypothyroidism.
Paper Details　
Original Abstract of the Article :
CONTEXT: The pharmacokinetics of liothyronine causes concerns for cardiovascular toxicity. While the effects of sustained increase in serum T3 concentrations are well described, little is known on the effects of acute changes in T3 concentrations due to rapid action of thyroid hormone. OBJECTIVE: T...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919711/

データ提供：米国国立医学図書館（NLM）

The Effects of Liothyronine on Cardiovascular System and Energy Metabolism

In the realm of [endocrinology], a key concern revolves around the potential cardiovascular risks associated with liothyronine, a synthetic thyroid hormone. While the impact of sustained elevated serum T3 levels is well documented, the effects of acute fluctuations in T3 levels remain largely unexplored. This research delves into the intriguing question: how does a sudden surge in T3 levels influence the cardiovascular system and energy metabolism? The researchers employed a double-blind, placebo-controlled crossover study with 12 healthy volunteers to investigate this intriguing question.

Liothyronine: A Speedy Surge

They administered a high dose of liothyronine, an equimolar dose of levothyroxine, or a placebo to participants. They meticulously monitored heart rate, blood pressure, hemodynamic data, and energy expenditure, keeping a close eye on the changes in serum T3 levels. Their findings revealed that while there was a swift rise in serum T3 levels after liothyronine administration, there was a surprising lack of significant immediate effects on the cardiovascular system.

A Gentle Heart

The researchers noted no dramatic changes in heart rate, blood pressure, or energy metabolism. This suggests that the cardiovascular system is quite resilient to short-term changes in T3 levels. These initial observations pave the way for future long-term studies to thoroughly assess the safety and efficacy of liothyronine in patients with hypothyroidism.

Health Implications and Applications

These findings are a reassuring oasis in the desert of potential cardiovascular risks associated with liothyronine. The lack of immediate adverse effects offers a glimmer of hope for those seeking a safe and effective treatment for hypothyroidism.

Dr. Camel's Conclusion

This study is akin to a refreshing breeze in the desert, providing evidence that liothyronine might not be the cardiovascular risk factor some initially feared. While further long-term studies are needed, these initial findings offer a beacon of hope for patients seeking a safe and effective treatment for hypothyroidism.
Date :
  1. Date Completed 2022-04-25
  2. Date Revised 2023-05-03
Further Info :

Pubmed ID

35295986

DOI: Digital Object Identifier

PMC8919711

SNS
PICO Info
in preparation
Languages

English

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