Paper Details

  1. Home
  2. Paper Details

SUPPLEMENT ARTICLE: A Novel Drug Delivery Method: Retrometabolic Drug Design.

Author: ArmstrongApril, ChadhaDeepak, KircikLeon, ReddyRasika

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Soft drugs are a class of drugs designed to be rapidly metabolized to inactive metabolites after exerting their activity at their target site. This approach minimizes systemic toxicity while enhancing local efficacy. Sofpironium bromide, a soft anticholinergic drug, has been explored for the treatment of primary axillary hyperhidrosis. It has demonstrated efficacy and safety in Phase II and Phase III clinical trials, suggesting its potential utility in dermatology.
Paper Details　
Original Abstract of the Article :
Soft drugs, a class of retrometabolic drug design, contain a metabolically sensitive moiety that promotes rapid metabolism to inactive metabolites after exerting activity at its target site. The goal of soft drugs is to reduce systemic toxicity while enhancing local efficacy. Soft drugs have been ap...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/35389593

データ提供：米国国立医学図書館（NLM）

Soft Drugs: A New Frontier in Drug Design

The field of drug design is constantly evolving, and this research explores a new and innovative approach – retrometabolic drug design. This approach focuses on creating "soft drugs", which are designed to be rapidly metabolized to inactive forms after exerting their therapeutic effects. This strategy aims to minimize systemic toxicity while enhancing local efficacy.

The study highlights the application of soft drug design in dermatology. It discusses various examples of soft drugs, such as soft JAK inhibitors and soft TRPV1 inhibitors, which are being investigated for the treatment of inflammatory and autoimmune dermatological conditions. The study also focuses on sofpironium bromide, a soft anticholinergic drug approved for the treatment of primary axillary hyperhidrosis.

Retrometabolic Drug Design: A Promising Approach for Dermatological Conditions

The study reveals the growing importance of retrometabolic drug design in dermatology. It demonstrates the efficacy and safety of soft drugs in treating various dermatological conditions, particularly those related to inflammation and autoimmune disorders.

Minimizing Side Effects and Enhancing Local Efficacy: The Promise of Soft Drugs

Soft drugs offer a new paradigm in drug design by minimizing systemic toxicity and enhancing local efficacy. This approach has the potential to improve the therapeutic landscape for a variety of conditions, including dermatological disorders. Soft drugs are like a gentle breeze that effectively cools a targeted area without causing widespread disturbances in the body.

Dr. Camel's Conclusion

This research, like a caravan traversing the desert, has opened up a new and promising route in drug design. The development of soft drugs represents a significant advancement in the field of medicine, particularly in dermatology. By minimizing side effects and maximizing local efficacy, soft drugs offer a more targeted and patient-centric approach to treatment.

Date :
  1. Date Completed 2022-04-11
  2. Date Revised 2022-04-11
Further Info :

Pubmed ID

35389593

DOI: Digital Object Identifier

S1545961622S00s5X

Related Literature

Article Analysis
・Side Effects of glycopyrronium topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.