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Trimipramine in the treatment of gastric ulcer.

Author: MyrenJ, QvigstadT, ValnesK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Trimipramine (50 mg daily before bedtime) was significantly more effective than placebo in healing gastric ulcers. After four weeks, 12 out of 20 patients on trimipramine experienced complete ulcer healing, compared to 4 out of 20 on placebo. No serious side-effects occurred.
Paper Details　
Original Abstract of the Article :
Forty patients with endoscopically confirmed gastric ulcers, completed a double-blind study comparing trimipramine with placebo during 4 weeks' treatment. The daily dose of trimipramine was 50 mg given before bedtime. No serious side-effects occurred. After four weeks' treatment 12 of the 20 patient...See full text at original site
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引用元：
https://doi.org/10.3109/00365527809181928

データ提供：米国国立医学図書館（NLM）

Exploring the Therapeutic Potential of Trimipramine for Gastric Ulcers

This study investigates the effectiveness of trimipramine, a drug traditionally used for depression, in the treatment of gastric ulcers. The researchers conducted a double-blind study comparing trimipramine to a placebo in 40 patients with confirmed gastric ulcers. The results revealed that trimipramine led to a significantly higher rate of ulcer healing compared to the placebo, highlighting its potential as a treatment option for peptic ulcer disease.

Trimipramine's Promise for Gastric Ulcer Treatment

This study demonstrated that trimipramine significantly improved ulcer healing in patients with confirmed gastric ulcers. The researchers observed a statistically significant difference between the trimipramine group and the placebo group, with a greater number of patients experiencing complete ulcer healing in the trimipramine group. This suggests that trimipramine could be a valuable addition to the therapeutic arsenal for treating peptic ulcer disease.

Managing Gastric Ulcers: A Holistic Approach

This research underscores the importance of a multi-faceted approach to managing gastric ulcers. While trimipramine shows promise, it's essential to consult with a healthcare professional for a comprehensive diagnosis and treatment plan. Maintaining a healthy lifestyle, managing stress, and adhering to prescribed medications are crucial components of successful ulcer management.

Dr.Camel's Conclusion

This study, much like a camel traversing a vast desert, offers a novel perspective on the treatment of gastric ulcers. It challenges traditional thinking by demonstrating the effectiveness of an unexpected drug, trimipramine, in promoting ulcer healing. This research paves the way for future investigations and may lead to new therapeutic approaches for managing this common ailment.

Date :
  1. Date Completed 1978-09-25
  2. Date Revised 2019-08-14
Further Info :

Pubmed ID

353969

DOI: Digital Object Identifier

10.3109/00365527809181928

Related Literature

Article Analysis
・Side Effects of trimipramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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