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Comparison of diflunisal and piroxicam in the management of patients with osteoarthritis.

Author: BaumgartnerS W, LainD, LewisT

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Diflunisal and piroxicam were both effective in treating osteoarthritis. Diflunisal was associated with a greater reduction in night pain. Both drugs were generally well tolerated.
Paper Details　
Original Abstract of the Article :
An open-label comparison of diflunisal, a nonacetylated salicylate nonsteroidal anti-inflammatory drug (NSAID), and piroxicam, an NSAID belonging to the oxicam family, was conducted in patients with osteoarthritis. Efficacy assessments were made biweekly by the physician and patients during a 12-wee...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3548983

データ提供：米国国立医学図書館（NLM）

Diflunisal vs. Piroxicam: A Comparative Look at Osteoarthritis Treatment

This open-label comparative study investigates the efficacy and safety of [diflunisal] and [piroxicam], two nonsteroidal anti-inflammatory drugs (NSAIDs), in treating [osteoarthritis]. The researchers evaluated the effects of each medication on various symptoms of [osteoarthritis], including [knee pain], [tenderness], [swelling], [stiffness], and [difficulty walking], over a 12-week treatment period.

Diflunisal and Piroxicam: Similar Efficacy, Different Tolerability

The study found that both [diflunisal] and [piroxicam] were effective in reducing the symptoms of [osteoarthritis], but [diflunisal] was more effective in relieving [night pain]. Both medications were generally well tolerated, but [diflunisal] had fewer reported [adverse effects] than [piroxicam]. This suggests that [diflunisal] may be a preferable option for some patients with [osteoarthritis].

Choosing the Right NSAID for Osteoarthritis: A Personal Journey

This study emphasizes the importance of individualizing treatment for [osteoarthritis]. Just as a camel adapts to the unique challenges of a particular desert, patients with [osteoarthritis] may respond differently to different medications. The study highlights the need for careful consideration of individual patient needs and the potential side effects of various treatment options.

Dr.Camel's Conclusion

This study provides a valuable comparison of two common NSAIDs used to treat [osteoarthritis], highlighting the importance of considering individual patient needs and tolerability when selecting the most appropriate medication. The research underscores the importance of a personalized approach to treatment, ensuring that patients receive the most effective and safe care possible.

Date :
  1. Date Completed 1987-04-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3548983

DOI: Digital Object Identifier

3548983

Related Literature

Article Analysis
・Side Effects of diflunisal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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