Efficacy of a fixed-dose combination of 40 mg penbutolol with 6 mg piretanide in the treatment of mild to moderate hypertension: a double-blind study against placebo.

Author: RangoonwalaB, VerhoM, YaskyJ

Paper Details 
Original Abstract of the Article :
The antihypertensive efficacy and tolerability of a fixed-dose combination containing 40 mg penbutolol (a beta-blocking agent) and 6 mg piretanide (a diuretic) in comparison to placebo was investigated in a double-blind, crossover study in 20 patients with mild to moderate essential hypertension. Af...See full text at original site
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引用元:
https://doi.org/10.1185/03007998709111109

データ提供:米国国立医学図書館(NLM)

A Fixed-Dose Combination for Hypertension: Navigating the Sands of Blood Pressure Control

This research embarks on a fascinating journey into the realm of [hypertension treatment], exploring the efficacy and safety of a [fixed-dose combination] of [penbutolol] and [piretanide]. The study, a [double-blind, crossover design], investigated the effects of this combination compared to [placebo] in individuals with [mild to moderate essential hypertension]. The results revealed that the [fixed-dose combination] significantly reduced both [systolic] and [diastolic blood pressure], demonstrating its potential in managing [hypertension]. The study also highlighted the [tolerability] of the combination, with minimal side effects observed. These findings suggest that this [fixed-dose combination] could be a valuable tool in the fight against [hypertension], offering a convenient and effective treatment option.

The Promise of a Fixed-Dose Combination: Navigating the Sands with Greater Ease

This research provides compelling evidence for the effectiveness of [fixed-dose combinations] in managing [hypertension]. The study's results suggest that [fixed-dose combinations] may offer a more convenient and potentially more effective approach to [hypertension] treatment compared to single-agent therapies. The findings underscore the potential for further investigation into the role of [fixed-dose combinations] in optimizing [hypertension] management.

Navigating the Desert of Blood Pressure: A Personalized Approach

This research emphasizes the importance of a personalized approach to [hypertension] management. The study's findings highlight the need for healthcare providers to carefully consider the individual needs and sensitivities of patients when prescribing [hypertension medications]. By embracing a personalized approach, we can optimize treatment outcomes and ensure that individuals living with [hypertension] have the best chance of achieving optimal blood pressure control and maintaining their overall health.

Dr. Camel's Conclusion

Just as a camel adapts to the desert's unique environment, we must approach the challenges of hypertension with a personalized strategy. This research underscores the importance of finding the right combination of therapies to effectively manage this prevalent health condition. By exploring innovative treatment options like fixed-dose combinations, we can navigate the vast and complex desert of hypertension with greater precision and success.

Date :
  1. Date Completed 1987-05-26
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3552458

DOI: Digital Object Identifier

10.1185/03007998709111109

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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