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Losartan Alleviates the Side Effects and Maintains the Anticancer Activity of Axitinib.
Author: ChenXiaoxuan, FuYing, RidwanKadir Ahmad, SaxuRengui, TengYuou, XuXueping, YaoJiaping, YuPeng, ZhengWeida
Original Abstract of the Article :
Axitinib is one of the most potent inhibitors of the vascular endothelial growth factor (VEGF) receptor and shows strong antitumor activity toward various malignant tumors. However, its severe side effects affect the quality of life and prognosis of patients. Losartan, which functions as a typical a...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101101/
データ提供:米国国立医学図書館(NLM)
Losartan: A Potential Ally in Managing Axitinib Side Effects
This study explores the potential of [losartan], an [angiotensin receptor blocker], to alleviate the side effects of [axitinib], a potent [vascular endothelial growth factor (VEGF) receptor] inhibitor used in cancer treatment. The authors investigated the effects of losartan on the blood pressure elevation and other side effects induced by axitinib in animal models. They found that losartan effectively reduced the blood pressure increase caused by axitinib while maintaining the drug's antitumor activity.A New Approach to Managing Axitinib Side Effects
This study offers a promising approach to mitigating the side effects associated with axitinib, a powerful anti-cancer drug. The authors' findings suggest that losartan can effectively reduce the blood pressure elevation caused by axitinib without compromising its antitumor activity. It's like finding a way to make a desert oasis more hospitable, mitigating the harsh conditions while preserving the benefits of the environment. This research could lead to improved patient comfort and adherence to axitinib therapy.Balancing Therapeutic Benefits with Side Effect Management
This study highlights the importance of balancing therapeutic benefits with side effect management in cancer treatment. The authors' findings suggest that losartan could be a valuable tool for managing the side effects of axitinib, potentially improving patient quality of life and treatment compliance. It's like finding a path through a desert that offers both shade and sustenance, ensuring a safe and productive journey. This research emphasizes the need for ongoing efforts to develop strategies that minimize side effects and maximize the benefits of anti-cancer therapies.Dr. Camel's Conclusion
This study explores the potential of losartan, an angiotensin receptor blocker, to alleviate the side effects of axitinib, a potent VEGF receptor inhibitor used in cancer treatment. The authors' findings suggest that losartan can effectively reduce the blood pressure increase caused by axitinib while maintaining the drug's antitumor activity. It's like finding a way to make a desert oasis more hospitable, mitigating the harsh conditions while preserving the benefits of the environment. This research could lead to improved patient comfort and adherence to axitinib therapy.Date :
- Date Completed 2022-05-19
- Date Revised 2022-07-16
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