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The efficiency and safety of alendronate versus teriparatide for treatment glucocorticoid-induced osteoporosis: A meta-analysis and systematic review of randomized controlled trials.

Author: GuanXiao-Qing, LiuZhi-Ming, ShenZhu-Bin, YinFei, ZhangDing, ZhangMin, ZongYuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Teriparatide (TPTD) was more effective than alendronate (ALE) in reducing vertebral fracture risk in patients with glucocorticoid-induced osteoporosis (GIOP). Long-term use of TPTD increased bone mineral density in the lumbar spine, femoral neck, and total hip, while there was no significant difference in the incidence of non-vertebral fracture and adverse events between the two groups.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis, alendronate (ALE) and teriparatide (TPTD) are widely used in the treatment of GIOP. However, which of these two drugs has a better curative effect needs the support of evidence-based medicine. METHODS:...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154179/

データ提供：米国国立医学図書館（NLM）

Alendronate vs. Teriparatide: Navigating the Desert of Glucocorticoid-Induced Osteoporosis

The [glucocorticoid-induced osteoporosis (GIOP)] desert is a harsh and unforgiving landscape, where bones become as brittle as desert sand. This study explores the [effectiveness and safety] of [alendronate] versus [teriparatide] in the treatment of GIOP. It's like comparing two different paths through the desert, seeking the most effective way to strengthen weakened bones.

Teriparatide: A Stronger Path Through the GIOP Desert

The study reveals that [teriparatide] is more effective than [alendronate] in [reducing the rate of new vertebral fracture] in [patients with GIOP]. It's like finding a path that leads to greater bone density and a more stable foundation. Teriparatide also showed a significant increase in [bone mineral density (BMD)] compared to alendronate, especially in the [lumbar spine], [femoral neck], and [total hip]. This suggests that teriparatide may be a more powerful tool for combating bone loss associated with GIOP.

Navigating the GIOP Desert with a Focus on Bone Health

This research highlights the importance of choosing the right treatment strategy for [GIOP]. It's like selecting the right camel for the desert journey, choosing the one that is best suited for the terrain and the goals of the traveler. The study underscores the need for careful consideration of [bone density], [fracture risk], and [individual patient needs] when making treatment decisions.

Dr.Camel's Conclusion

The journey through the GIOP desert can be challenging, but this research offers valuable insights into the different paths to recovery. It's a reminder that the desert is not a monolithic landscape, but rather a complex ecosystem with a variety of potential solutions. As we continue our journey, we must remain vigilant, seeking the most effective strategies to strengthen our bones and maintain our overall health.

Date :
  1. Date Completed 2022-06-02
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

35639783

DOI: Digital Object Identifier

PMC9154179

Related Literature

Article Analysis
・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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